Alfimova M V, Golimbet V E, Korovaĭtseva G I, Lezheĭko T V, Abramova L I, Kaleda V G, Barkhatova A N
Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(1):46-51.
An association between serotonin transporter gene 5-HTTLPR polymorphism and development of depressive states in response to different distant and proximal stressors has been reported previously. We studied 5-HTTLPR polymorphism effect on probability of development of mental maladaptation and its peculiarities in 224 relatives of patients with severe chronic mental disorders: schizophrenia, schizoaffective and affective disorders. The SS genotype was associated with elevation on the scale Hypochondriasis of the MMPI that indicated intensity of the autonomic component of anxiety and more concern about health as well as increased sensitivity. At the same time, its relation to depression and anxiety measured by the scale Depression was tentative. The association was stronger in men than in women. Moreover, men with the SS genotype were more tense, suspicious, detached and experienced difficulties in concentration (scales Paranoia and Schizophrenia) as compared to those with other genotypes. The results imply a role of the short allele in augmenting and modulation of psychopathological reaction in response to chronic stressful situation in relatives of psychotic patients.
先前已有报道称，血清素转运体基因5-HTTLPR多态性与应对不同远近应激源时抑郁状态的发展之间存在关联。我们研究了5-HTTLPR多态性对224名患有严重慢性精神障碍（精神分裂症、分裂情感性障碍和情感性障碍）患者亲属出现心理适应不良的概率及其特点的影响。SS基因型与明尼苏达多相人格调查表（MMPI）中疑病量表得分升高有关，这表明焦虑自主成分的强度以及对健康的更多关注和更高的敏感性。与此同时，其与抑郁量表所测量的抑郁和焦虑之间的关系尚不确定。这种关联在男性中比在女性中更强。此外，与其他基因型的男性相比，具有SS基因型的男性更紧张、多疑、冷漠，并且在注意力集中方面存在困难（偏执狂和精神分裂症量表）。结果表明，短等位基因在增强和调节精神病患者亲属对慢性应激情况的心理病理反应中发挥作用。
