Alfimova M V, Golimbet V E, Korovaitseva G I, Lezheiko T V, Abramova L I, Kaleda V G, Barkhatova A N
Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Neurosci Behav Physiol. 2008 Mar;38(3):253-8. doi: 10.1007/s11055-008-0037-8.
A number of studies have reported an association between 5-HTTLPR, a polymorphism of the serotonin transporter gene, and the development of depressive states in response to a variety of distal and proximal stressors. We report here studies of the effects of the 5-HTTLPR polymorphism on the probability that an individual will develop mental maladaptation in 224 close relatives of patients with severe chronic mental disorders - schizophrenia and schizoaffective and affective psychoses. The ss genotype of the serotonin transporter gene contributes to the formation predominantly of manifestations of distress, reflected by increases on the hypochondriasis scale of the MMPI scale of factors such as the extent of the autonomic component of anxiety reactions and increased attention to own health, as well as increases in sensitivity. At the same time, the ss genotype was less likely to influence the appearance of depression and anxiety, as determined on the depression scale. These tendencies were more marked in males than females. Furthermore, males with the ss genotype were characterized by some increase in tension, suspicion, detachment, and attention difficulty (on the paranoia and schizophrenia scales). These data can be regarded as supporting the role of the short allele of the serotonin transporter gene in enhancing and modulating psychopathological reactions to chronic stress situations in relatives of mental patients.
多项研究报告了血清素转运体基因的一种多态性——5-羟色胺转运体基因相关多态性区域（5-HTTLPR）与针对各种远期和近期应激源产生的抑郁状态之间的关联。我们在此报告对5-HTTLPR多态性在224名严重慢性精神障碍患者（精神分裂症、分裂情感性精神病和情感性精神病）的近亲中出现心理适应不良可能性方面影响的研究。血清素转运体基因的ss基因型主要促成了痛苦表现的形成，这体现在明尼苏达多相人格调查表（MMPI）的疑病量表上的增加，如焦虑反应自主成分的程度增加以及对自身健康的关注度增加等因素，还有敏感性增加。同时，如在抑郁量表上所确定的，ss基因型影响抑郁和焦虑出现的可能性较小。这些倾向在男性中比在女性中更明显。此外，具有ss基因型的男性表现为紧张、猜疑、疏离和注意力困难（在偏执和精神分裂症量表上）有所增加。这些数据可被视为支持血清素转运体基因短等位基因在增强和调节精神病患者亲属对慢性应激情况的心理病理反应中的作用。
