神经元钙传感器蛋白：产生神经元钙信号的多样性
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.
作者信息
Burgoyne Robert D
机构信息
The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, UK.
出版信息
Nat Rev Neurosci. 2007 Mar;8(3):182-93. doi: 10.1038/nrn2093.
Abstract
In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.
摘要
在神经元中，细胞内钙信号在激活神经递质释放以及触发神经元功能改变方面发挥着关键作用。钙调蛋白作为一种Ca(2+)传感器已得到广泛研究，它在神经元Ca(2+)信号传导中具有多种明确的作用，但神经元钙传感器蛋白家族的成员也已开始成为许多调节途径中的关键成分，并增加了神经元Ca(2+)信号传导途径的多样性。这些蛋白质的不同特性使它们具有离散的、非冗余的功能。
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