Jesudason David R, Monteiro Mariana P, McGowan Barbara M C, Neary Nicola M, Park Adrian J, Philippou Elena, Small Caroline J, Frost Gary S, Ghatei Mohammad A, Bloom Stephen R
Department of Metabolic Medicine, Faculty of Medicene, Imperial College London, London, UK.
Br J Nutr. 2007 Mar;97(3):426-9. doi: 10.1017/S0007114507336799.
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to food ingestion and remains elevated for up to 6 h postprandially. Plasma levels are elevated in patients with pancreatic tumours. An intravenous infusion of PP has been reported to reduce food intake in man, suggesting that PP is a satiety hormone. We investigated whether a lower infusion rate of PP would induce significant alterations in energy intake. The study was randomised and double-blinded. Fourteen lean fasted volunteers (five men and nine women) received 90 min infusions of PP (5 pmol/kg per min) and saline on two separate days. The dose chosen was half that used in a previous human study which reported a decrease in appetite but at supra-physiological levels of PP. One hour after the end of the infusion, a buffet lunch was served and energy intake measured. PP infusion was associated with a significant 11 % reduction in energy intake compared with saline (2440 (se 200) v. 2730 (se 180) kJ; P<0 x 05). Preprandial hunger as assessed by a visual analogue score was decreased in the PP-treated group compared to saline. These effects were achieved with plasma levels of PP within the pathophysiological range of pancreatic tumours.
胰多肽（PP）是一种肠道激素，在摄入食物后从胰腺释放，餐后可升高长达6小时。胰腺肿瘤患者的血浆水平会升高。据报道，静脉输注PP可减少人体的食物摄入量，这表明PP是一种饱腹感激素。我们研究了较低输注速率的PP是否会引起能量摄入的显著变化。该研究为随机双盲研究。14名空腹的瘦志愿者（5名男性和9名女性）在两个不同的日子分别接受了90分钟的PP（5 pmol/kg每分钟）输注和生理盐水输注。所选剂量是先前一项人体研究中使用剂量的一半，该研究报告了食欲下降，但PP处于超生理水平。输注结束1小时后，提供自助午餐并测量能量摄入量。与生理盐水相比，输注PP导致能量摄入量显著降低了11%（2440（标准误200）对2730（标准误180）千焦；P<0.05）。与生理盐水相比，PP治疗组通过视觉模拟评分评估的餐前饥饿感有所降低。这些效应是在PP血浆水平处于胰腺肿瘤病理生理范围内实现的。
