Batterham R L, Le Roux C W, Cohen M A, Park A J, Ellis S M, Patterson M, Frost G S, Ghatei M A, Bloom S R
Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom.
J Clin Endocrinol Metab. 2003 Aug;88(8):3989-92. doi: 10.1210/jc.2003-030630.
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to ingestion of food. Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition peripheral administration of PP has been shown to decrease food intake in rodents. These findings suggest that PP may act as a circulating factor that regulates food intake. Therefore we investigated the effect of intravenous infusion of PP (10 pmol/kg/min) on appetite and food intake in a randomised double-blind placebo-controlled crossover study in ten healthy volunteers. Infusion of PP reduced appetite and decreased the energy intake at a buffet lunch two hours post-infusion by 21.8 +/- 5.7% (P < 0.01). More importantly the inhibition of food intake was sustained, such that energy intake, as assessed by food diaries, was significantly reduced both the evening of the study and the following morning. Overall PP infusion reduced cumulative 24-hour energy intake by 25.3 +/- 5.8%. In conclusion our data demonstrates that PP causes a sustained decrease in both appetite and food intake.
胰多肽（PP）是一种肠道激素，在摄入食物时从胰腺释放。血浆PP已被证明在与食物摄入量增加相关的情况下会降低，而在神经性厌食症中会升高。此外，已表明对啮齿动物外周给予PP会减少食物摄入量。这些发现表明PP可能作为一种调节食物摄入的循环因子。因此，我们在一项针对10名健康志愿者的随机双盲安慰剂对照交叉研究中，研究了静脉输注PP（10 pmol/kg/分钟）对食欲和食物摄入的影响。输注PP降低了食欲，并使输注后两小时的自助餐午餐时的能量摄入量减少了21.8±5.7%（P < 0.01）。更重要的是，对食物摄入的抑制持续存在，以至于通过食物日记评估的能量摄入量在研究当晚和第二天早上均显著降低。总体而言，PP输注使24小时累积能量摄入量降低了25.3±5.8%。总之，我们的数据表明PP会导致食欲和食物摄入量持续下降。
