Wang Hsuan-Chi, Chen Po See, Lee I Hui, Yang Yen Kuang, Yeh Tzung Lieh, Lu Ru-Band
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.
Neuropsychobiology. 2006;54(3):182-5. doi: 10.1159/000099945. Epub 2007 Feb 21.
Weight gain is a common adverse effect associated with olanzapine treatment. Another side effect of olanzapine treatment is a significant increase in circulating leptin levels. This preliminary study monitored the changes in leptin levels for 2 weeks after olanzapine treatment had been initiated. The relationship between the changes in circulating leptin levels and alterations in body weight in 9 patients with schizophrenia who received olanzapine was examined. The results showed that olanzapine may cause a surge in circulating leptin levels before weight gain is manifested. Moreover, higher pretreatment circulating leptin levels predicted lower weight gains after olanzapine treatments (r = -0.93; p < 0.05) after controlling for the effect of sex.
体重增加是与奥氮平治疗相关的常见不良反应。奥氮平治疗的另一个副作用是循环瘦素水平显著升高。这项初步研究监测了开始奥氮平治疗后2周内瘦素水平的变化。研究了9例接受奥氮平治疗的精神分裂症患者循环瘦素水平变化与体重改变之间的关系。结果表明，在体重增加表现出来之前，奥氮平可能会导致循环瘦素水平激增。此外，在控制性别影响后，治疗前较高的循环瘦素水平预示着奥氮平治疗后体重增加较少（r = -0.93；p < 0.05）。
