Lincoln Alan J, Searcy Yvonne M, Jones Wendy, Lord Catherine
Dr. Lincoln, Ms. Searcy, and Dr. Jones are with the Salk Institute for Biological Studies Laboratory for Cognitive Neuroscience; Dr. Lincoln is also with Alliant International University, California School of Professional Psychology-San Diego; and Dr. Lord is with University of Michigan.
Dr. Lincoln, Ms. Searcy, and Dr. Jones are with the Salk Institute for Biological Studies Laboratory for Cognitive Neuroscience; Dr. Lincoln is also with Alliant International University, California School of Professional Psychology-San Diego; and Dr. Lord is with University of Michigan.
J Am Acad Child Adolesc Psychiatry. 2007 Mar;46(3):323-331. doi: 10.1097/chi.0b013e31802b9522.
Autistic disorder (AD) and Williams syndrome (WS) are neurodevelopmental disorders characterized by contrasting abnormal social behavior (the former, socially avoidant; the latter, outwardly social); nonetheless, there are individuals with WS who display some behaviors that are characteristic of AD. We quantified the extent to which autism spectrum disorder (ASD) behaviors were present in children with WS.
Twenty children with WS (27-58 months) and 26 age- and IQ-equivalent children with AD were administered the Autism Diagnostic Observation Schedule (ADOS). ADOS behaviors were compared between groups.
Two children with WS met DSM-IV criteria for AD, one of whom was also classified as having AD by the ADOS algorithm. Discriminant analysis of ADOS behaviors indicated that gesture, showing, and quality of social overtures best discriminated the groups.
Although some children with WS demonstrated some ASD behaviors, and a minority of children with WS had coexisting AD, the symptom profile in WS was different from AD. Despite some deficits in communication behaviors, showing, and initiating joint attention, children with WS made social overtures and efforts to engage others, whereas children with AD tended not to do so.
孤独症谱系障碍（AD）和威廉姆斯综合征（WS）是神经发育障碍，其特征是具有相反的异常社会行为（前者社交回避；后者外向社交）；然而，有一些WS患者表现出一些AD特有的行为。我们对WS患儿中孤独症谱系障碍（ASD）行为出现的程度进行了量化。
对20名WS患儿（27 - 58个月）和26名年龄及智商匹配的AD患儿进行了孤独症诊断观察量表（ADOS）测试。比较了两组之间的ADOS行为。
两名WS患儿符合AD的DSM-IV标准，其中一名根据ADOS算法也被归类为患有AD。对ADOS行为的判别分析表明，手势、展示和社交主动行为的质量最能区分两组。
虽然一些WS患儿表现出一些ASD行为，少数WS患儿同时患有AD，但WS的症状特征与AD不同。尽管WS患儿在沟通行为、展示和发起共同注意方面存在一些缺陷，但他们会主动进行社交并努力与他人互动，而AD患儿则往往不会这样做。
