患有威廉姆斯综合征且具有短语言语或流利语言的儿童的自闭症谱系症状。
Autism Spectrum Symptomatology in Children with Williams Syndrome Who Have Phrase Speech or Fluent Language.
机构信息
Department of Psychology, University of Wisconsin-Milwaukee, P.O. Box 413, Milwaukee, WI, 53201, USA.
Northwest Kaiser Permanente, 3550 N Interstate Avenue, Portland, OR, 97227, USA.
出版信息
J Autism Dev Disord. 2018 Sep;48(9):3037-3050. doi: 10.1007/s10803-018-3555-4.
Abstract
To characterize autism spectrum-related symptomatology in children with Williams syndrome (WS) with phrase speech or fluent language, the Autism Diagnostic Observation Schedule Module 2 or 3 was administered. The cutoff for autism spectrum was met by 35% (14/40) who completed Module 2 and 30% (18/60) who completed Module 3. Similarities and differences in socio-communicative strengths and weaknesses as a function of language ability were identified. Symptom severity was negatively associated with IQ for participants with phrase speech but not for those with fluent language. The findings suggest an elevated risk of ASD for individuals with WS relative to the general population and contribute to a more nuanced sense of the socio-communicative functioning of children with WS.
摘要
为了描述具有短语言语或流畅语言的威廉姆斯综合征（WS）儿童的自闭症谱系相关症状，使用自闭症诊断观察量表模块 2 或 3 进行了评估。完成模块 2 的儿童中有 35%（14/40）符合自闭症谱系的标准，完成模块 3 的儿童中有 30%（18/60）符合自闭症谱系的标准。确定了语言能力对社会交际能力强弱的相似和差异。对于具有短语言语的参与者，症状严重程度与智商呈负相关，但对于具有流畅语言的参与者则不是。这些发现表明，WS 个体患 ASD 的风险相对一般人群较高，并有助于更细致地了解 WS 儿童的社会交际功能。
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本文引用的文献
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2
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J Autism Dev Disord. 2018 Jan;48(1):326-331. doi: 10.1007/s10803-017-3319-6.
3
Williams syndrome deletions and duplications: Genetic windows to understanding anxiety, sociality, autism, and schizophrenia.
Neurosci Biobehav Rev. 2017 Aug;79:14-26. doi: 10.1016/j.neubiorev.2017.05.004. Epub 2017 May 10.
4
Anxiety Disorders in Williams Syndrome Contrasted with Intellectual Disability and the General Population: A Systematic Review and Meta-Analysis.
J Autism Dev Disord. 2017 Dec;47(12):3765-3777. doi: 10.1007/s10803-016-2909-z.
5
Parent and Self-Report Ratings on the Perceived Levels of Social Vulnerability of Adults with Williams Syndrome.
J Autism Dev Disord. 2016 Nov;46(11):3424-3433. doi: 10.1007/s10803-016-2885-3.
6
Symmetrical Dose-Dependent DNA-Methylation Profiles in Children with Deletion or Duplication of 7q11.23.
Am J Hum Genet. 2015 Aug 6;97(2):216-27. doi: 10.1016/j.ajhg.2015.05.019. Epub 2015 Jul 9.
7
Children with Williams syndrome: Developmental trajectories for intellectual abilities, vocabulary abilities, and adaptive behavior.
Am J Med Genet C Semin Med Genet. 2015 Jun;169(2):158-71. doi: 10.1002/ajmg.c.31436. Epub 2015 May 18.
8
Children with 7q11.23 duplication syndrome: psychological characteristics.
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9
Toward a deeper characterization of the social phenotype of Williams syndrome: The association between personality and social drive.
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Evaluation of a stranger safety training programme for adults with Williams syndrome.
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