Wong H Y
Adv Exp Med Biol. 1975;63:381-91. doi: 10.1007/978-1-4684-3258-9_29.
The chicken is a good animal model for the study of atherosclerosis research because it is: 1. Omnivorous. 2. Small and suitable for prolonged laboratory investigation. 3. Able to develop spontaneous atherosclerosis. 4. Capable of producing atherosclerosis after cholesterol feeding with elevated hypercholesterolemia. A diet of 1/4% cholesterol plus 5% cottonseed oil added to starter-grower-mash resulted in aortic atherosclerosis with a slight but significant increase in plasma cholesterol. 5. Plasma levels of cholesterol and triglyceride are similar to those in humans. 6. Lipid composition of high and low density lipoproteins as well as chylomicrons resembles those of humans. 7. Has been noted that there is no essential difference between vascular lesions seen in chickens as a result of cholesterol diet and that of atherosclerosis observed in man.
鸡是动脉粥样硬化研究的良好动物模型，因为它：1. 是杂食动物。2. 体型小，适合长时间的实验室研究。3. 能够自发形成动脉粥样硬化。4. 在喂食胆固醇导致高胆固醇血症后能够产生动脉粥样硬化。在雏鸡-生长鸡混合料中添加1/4%胆固醇和5%棉籽油的饮食会导致主动脉粥样硬化，同时血浆胆固醇略有但显著升高。5. 血浆胆固醇和甘油三酯水平与人类相似。6. 高密度和低密度脂蛋白以及乳糜微粒的脂质组成与人类相似。7. 已经注意到，喂食胆固醇饮食的鸡所出现的血管病变与人类观察到的动脉粥样硬化之间没有本质区别。
