Zashikhin A L, Bashilova E N, Selin Ia, Arkhipov A V
Urologiia. 2006 Nov-Dec(6):13-8.
Smooth muscular tissue (SMT) of human urinary system was studied at different levels (renal pelvis, proximal and distal parts of the ureter) in health and some urological diseases (vesicoureteral reflux, ureteral obstruction). The method of target cell dissociation was used. The volume of myocytes, nuclei, nuclear-cytoplasmic correlation were calculated. Content of DNA and cytoplasmic protein was studied cytospectrophotometrically. Electron-microscopic study was also made. Three types of myocytes with different structural-metabolic parameters were detected. There were significant differences in mean volumes of myocytes, cytophotometric indices of SMT in different parts of the urinary tracts related to the pattern of these zones functioning. A comparative analysis of intact and affected SMT of the distal ureter demonstrated changes in the structure of leiomyocytes population, optic density of cytoplasmic protein and proliferative activity of myocytes which correlated depending on the kind and change of functional load.
在健康状态以及一些泌尿系统疾病（膀胱输尿管反流、输尿管梗阻）情况下，对人体泌尿系统不同部位（肾盂、输尿管近端和远端）的平滑肌组织（SMT）进行了研究。采用了靶细胞解离方法。计算了肌细胞体积、细胞核、核质比。用细胞分光光度法研究了DNA和细胞质蛋白含量。还进行了电子显微镜研究。检测到三种具有不同结构代谢参数的肌细胞。与这些区域的功能模式相关，尿路不同部位的肌细胞平均体积、SMT的细胞光度学指标存在显著差异。对远端输尿管完整和病变的SMT进行的比较分析表明，平滑肌细胞群体结构、细胞质蛋白光密度和肌细胞增殖活性发生了变化，这些变化根据功能负荷的类型和变化而相互关联。
