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1990/1992年德国环境调查(GerES II):血液、尿液、头发、室内灰尘、饮用水和室内空气中选定环境污染物的参考浓度

The German Environmental Survey 1990/1992 (GerES II): reference concentrations of selected environmental pollutants in blood, urine, hair, house dust, drinking water and indoor air.

作者信息

Seifert B, Becker K, Helm D, Krause C, Schulz C, Seiwert M

机构信息

Federal Environmental Agency, Berlin, Germany.

出版信息

J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 1):552-65. doi: 10.1038/sj.jea.7500111.

Abstract

The German Environmental Survey (GerES) is a large-scale, representative population study that has been carried out three times up to now with a time interval of about 7 years. GerES I was performed in 1985/1986, GerES IIa in 1990/1991 in West Germany, and GerES IIb in 1991/1992 in East Germany, the former German Democratic Republic (GDR). In GerES II, blood, urine, and scalp hair samples of 4021 adults aged 25-69 years and of 736 children aged 6-14 years were analysed as well as environmental samples (house dust, drinking water, indoor and personal air, diet). Characteristics of the frequency distributions of the substances analysed in the different media were calculated. The geometric mean (GM) for lead, cadmium, and mercury in the blood of adults amounted to 45.3, 0.36, and 0.51 microg/l, respectively. The corresponding values of arsenic, cadmium, and mercury in urine were 6.3, 0.29, and 0.54 microg/l, respectively. The concentrations of lead in blood, cadmium in blood and urine, and mercury in blood are lower in children than in adults. The GM ofpentachlorophenol (PCP) in urine of adults was 2.67 microg/l and in urine of children, 4.15 microg/l. These results of GerES II were compared with the so-called HBM values which represent health-based exposure guidelines and have been defined by the Human Biomonitoring Commission (HBC) of the Federal Environmental Agency, interalia for lead in blood, cadmium in urine, mercury in blood and urine, and PCP in urine. They also provided asound basis for the setting of reference values to describe the status of the German population. A total of 1.8% and 0.6% of the German females in child-bearing age had a level of lead in blood higher than HBM-I (100 microg/l) and HBM-II ( 150 microg/l), respectively. One percent of the children had a blood lead level above HBM-I. House dust and drinking water were analysed to characterise exposure in the domestic environment. Arsenic, cadmium, and lead deposition in homes amounted to 5.4 ng/(m2 day), 11.7 ng/(m2 day), and 0.29 microg/(m2 day), respectively. In the content of vacuum cleaner bags, concentrations were 2.1,0.9, and 5.9 microg/g. PCP, lindane and permethrin could be detected in the house dust of most German households. The pollutant load of the drinking water is significantly influenced by the corrosion of pipe materials and fittings. The new EC limit value of 10 microg/l for lead was exceeded in 7.7% of the first draw samples. The relatively high percentage (14%) of samples from East Germany that exceeded the current German guideline value for formaldehyde of 0.1 ppm in indoor air may be explained by the widespread use of contaminated particleboard in the former GDR.

摘要

德国环境调查(GerES)是一项大规模、具有代表性的人群研究,截至目前已进行了三次,时间间隔约为7年。GerES I于1985/1986年开展,GerES IIa于1990/1991年在西德进行,GerES IIb于1991/1992年在东德,即前德意志民主共和国(GDR)开展。在GerES II中,对4021名年龄在25至69岁的成年人以及736名年龄在6至14岁的儿童的血液、尿液和头皮毛发样本,以及环境样本(室内灰尘、饮用水、室内和个人空气、饮食)进行了分析。计算了在不同介质中所分析物质的频率分布特征。成年人血液中铅、镉和汞的几何平均值(GM)分别为45.3、0.36和0.51微克/升。尿液中砷、镉和汞的相应值分别为6.3、0.29和0.54微克/升。儿童血液中的铅、血液和尿液中的镉以及血液中的汞浓度低于成年人。成年人尿液中五氯苯酚(PCP)的GM为2.67微克/升,儿童尿液中为4.15微克/升。将GerES II的这些结果与所谓的HBM值进行了比较,HBM值代表基于健康的暴露指南,由联邦环境局的人类生物监测委员会(HBC)确定,特别是针对血液中的铅、尿液中的镉、血液和尿液中的汞以及尿液中的PCP。它们还为设定参考值以描述德国人群的状况提供了坚实基础。德国育龄女性中分别有1.8%和0.6%的人血液中的铅水平高于HBM - I(100微克/升)和HBM - II(150微克/升)。1%的儿童血铅水平高于HBM - I。对室内灰尘和饮用水进行了分析,以表征家庭环境中的暴露情况。家庭中砷、镉和铅的沉积量分别为5.4纳克/(平方米·天)、11.7纳克/(平方米·天)和0.29微克/(平方米·天)。吸尘器袋中的含量分别为2.1、0.9和5.9微克/克。在大多数德国家庭的室内灰尘中可检测到PCP、林丹和氯菊酯。饮用水的污染物负荷受管道材料和配件腐蚀的显著影响。首次抽取的样本中有7.7%超过了铅的新欧盟限值10微克/升。东德样本中相对较高比例(14%)超过了德国目前室内空气中甲醛0.1 ppm的指导值,这可能是由于前东德广泛使用受污染的刨花板所致。

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