dos Santos Boaventura Antônio, Stralioto Selir M, Siqueira Marilda M, Ranieri Tani S, Bercini Marilina, Schermann Maria Tereza, Wagner Mário Bernardes, Silveira Themis R
Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Rev Panam Salud Publica. 2006 Nov;20(5):299-306. doi: 10.1590/s1020-49892006001000002.
We evaluated the seroprevalence for measles, mumps, and rubella in school-age children (6-12 years old) before and after the administration of three triple combined viral vaccines.
In two municipal schools of Rio Grande do Sul, Brazil, 692 blood samples were collected before vaccination and 636 samples 21 to 30 days after vaccination during 1996. IgG antibody seropositivity was investigated by enzyme-linked immunosorbent assay (measles and mumps with Enzygnost [Behring, Marburg, Germany]; rubella with Rubenostika [Organon Teknica, Boxtel, the Netherlands]). The vaccines compared were: A: E-Zagreb, L-Zagreb, and Wistar RA 27/3 (Tresivac); B: Moraten, J-Lynn, and Wistar RA 27/3 (M-M-R II); and C: Schwarz, Urabe AM-9, and Wistar RA 27/3 (Trimovax).
Before vaccination, 79.2% [95% confidence interval (CI)=76.0%-82.2%] of the samples were positive for measles, 69.4% (95% CI=65.8%-72.8%) for mumps, and 55.4% (95% CI=51.6%-59.2%) for rubella. After vaccination with the A, B, and C vaccines, seropositivity was 100.0%, 99.5%, and 100.0%, respectively for measles; 99.5%, 94.5%, and 92.0% for mumps; and 92.6%, 91.3%, and 88.6% for rubella.
About one-fifth (20.8%) of the schoolchildren who could have been vaccinated against measles at age 9 months had levels of antibodies insufficient for protection. In the sample of schoolchildren without previous vaccination against mumps and rubella, high proportions of susceptible levels were found. All vaccines were immunogenic, but vaccine A yielded a seroconversion rate of 99.5% for the mumps component, which was significantly higher than the other two vaccines (P<0.01).
我们评估了在接种三种三联联合病毒疫苗前后，学龄儿童（6至12岁）中麻疹、腮腺炎和风疹的血清阳性率。
1996年，在巴西南里奥格兰德州的两所市立学校，接种疫苗前采集了692份血样，接种疫苗21至30天后采集了636份血样。通过酶联免疫吸附测定法（使用Enzygnost[德国马尔堡贝林公司]检测麻疹和腮腺炎；使用Rubenostika[荷兰博克斯泰尔欧加农泰克尼卡公司]检测风疹）研究IgG抗体血清阳性情况。所比较的疫苗有：A：E-萨格勒布株、L-萨格勒布株和Wistar RA 27/3株（Tresivac）；B：莫拉坦株、J-林恩株和Wistar RA 27/3株（M-M-R II）；C：施瓦茨株、尿嘧啶核苷AM-9株和Wistar RA 27/3株（Trimovax）。
接种疫苗前，79.2%[95%置信区间（CI）=76.0%-82.2%]的样本麻疹呈阳性，69.4%（95%CI=65.8%-72.8%）的样本腮腺炎呈阳性，55.4%（95%CI=51.6%-59.2%）的样本风疹呈阳性。接种A、B和C三种疫苗后，麻疹的血清阳性率分别为100.0%、99.5%和100.0%；腮腺炎的血清阳性率分别为99.5%、94.5%和92.0%；风疹的血清阳性率分别为92.6%、91.3%和88.6%。
在9个月时本可接种麻疹疫苗的学龄儿童中，约五分之一（20.8%）的儿童抗体水平不足以提供保护。在未接种过腮腺炎和风疹疫苗的学龄儿童样本中，发现有高比例的易感水平。所有疫苗均具有免疫原性，但疫苗A针对腮腺炎成分的血清转化率为99.5%，显著高于其他两种疫苗（P<0.01）。
