Mirambo Mariam M, Michael Fausta, Nyawale Helmut, Mbugano Frank, Walwa Maneja B, Mahamba Dina, Msanga Delfina R, Okamo Bernard, Damiano Prisca, Mshana Stephen E
Department of Microbiology and Immunology, Catholic University of Health and Allied Sciences, Mwanza P.O. Box 1464, Tanzania.
Ministry of Health, Immunization and Vaccine Development Program, Dodoma P.O. Box 743, Tanzania.
Children (Basel). 2024 Jan 9;11(1):73. doi: 10.3390/children11010073.
Mumps is an acute contagious viral disease caused by paramyxovirus characterized by complications that include orchitis, oophoritis, aseptic meningitis, and spontaneous abortion among many others. This study reports high mumps IgG seropositivity among school-aged children in rural areas of the Mbeya region, information that might be useful in understanding the epidemiology of mumps and instituting appropriate control measures including vaccination. Between May and July 2023, a cross-sectional study involving 196 enrolled children aged 5-13 years was conducted. Sociodemographic information and other relevant information were collected using a structured data collection tool. Blood samples were collected and used to detect mumps immunoglobulin G antibodies using indirect enzyme-linked immunosorbent assay (ELISA). A descriptive analysis was performed using STATA version 15. The median age of the enrolled children was 13 (interquartile range (IQR): 8-13) years. The seropositivity of mumps IgG antibodies was 88.8% (174/196, 95% CI: 83.5-92.5). By multivariable logistic regression analysis, history of fever (OR: 5.36, 95% CI: 1.02-28.22, = 0.047) and sharing utensils (OR: 8.05, 95% CI: 1.99-32.65, = 0.003) independently predicted mumps IgG seropositivity. More than three-quarters of school-aged children in rural areas of the Mbeya region are mumps IgG-seropositive, which is significantly associated with the sharing of utensils and history of fever. This suggests that the virus is endemic in this region, which calls for further studies across the country so as to institute evidence-based, appropriate control measures including a vaccination program.
腮腺炎是一种由副粘病毒引起的急性传染性病毒性疾病，其并发症包括睾丸炎、卵巢炎、无菌性脑膜炎以及自然流产等多种情况。本研究报告了姆贝亚地区农村学龄儿童中腮腺炎IgG血清阳性率较高，这一信息可能有助于了解腮腺炎的流行病学情况并制定包括疫苗接种在内的适当控制措施。在2023年5月至7月期间，开展了一项涉及196名5至13岁在册儿童的横断面研究。使用结构化数据收集工具收集社会人口学信息和其他相关信息。采集血样并采用间接酶联免疫吸附测定（ELISA）检测腮腺炎免疫球蛋白G抗体。使用STATA 15版进行描述性分析。在册儿童的中位年龄为13岁（四分位间距（IQR）：8至13岁）。腮腺炎IgG抗体血清阳性率为88.8%（174/196，95%置信区间：83.5 - 92.5）。通过多变量逻辑回归分析，发热史（比值比：5.36，95%置信区间：1.02 - 28.22，P = 0.047）和共用器具（比值比：8.05，95%置信区间：1.99 - 32.65，P = 0.003）独立预测腮腺炎IgG血清阳性。姆贝亚地区农村超过四分之三的学龄儿童腮腺炎IgG血清呈阳性，这与共用器具和发热史显著相关。这表明该病毒在该地区为地方流行，这就需要在全国开展进一步研究，以便制定基于证据的适当控制措施，包括疫苗接种计划。
