McBee William C, Brainard Jennifer, Sawady Joram, Rose Peter G
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Case Western Reserve University, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Gynecol Oncol. 2007 Apr;105(1):244-7. doi: 10.1016/j.ygyno.2006.07.042. Epub 2007 Feb 21.
Mixed yolk sac tumors of the ovary are biologically aggressive even in early stage disease.
A 41-year-old woman presented with a large pelvic mass and anterior vaginal wall tumor. At surgery vaginal biopsies were performed followed by an exploratory laparotomy with resection of the mass. Pathology of the ovary revealed a primary yolk sac tumor associated with poorly differentiated endometrioid and undifferentiated carcinoma with vaginal metastasis only. She was initiated on bleomycin, etoposide, and cisplatin, with three additional cycles of etoposide and cisplatin. Initially the patient experienced a complete response, however her disease recurred and she currently is dead of her disease.
To our knowledge this is the first case of a mixed ovarian germ cell tumor with vaginal metastasis.
卵巢混合性卵黄囊瘤即使在疾病早期也具有生物学侵袭性。
一名41岁女性因盆腔巨大肿块及阴道前壁肿瘤就诊。手术时进行了阴道活检，随后进行了剖腹探查并切除肿块。卵巢病理显示为原发性卵黄囊瘤，伴有低分化子宫内膜样癌和未分化癌，仅发生阴道转移。给予她博来霉素、依托泊苷和顺铂治疗，随后又进行了三个周期的依托泊苷和顺铂治疗。最初患者有完全缓解，但疾病复发，目前已死于该疾病。
据我们所知，这是首例发生阴道转移的混合性卵巢生殖细胞肿瘤。
