Linka Thomas, Sartory Gudrun, Bender Stefan, Gastpar Markus, Müller Bernhard W
Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, 45147 Essen, Germany.
J Affect Disord. 2007 Nov;103(1-3):139-45. doi: 10.1016/j.jad.2007.01.018. Epub 2007 Feb 20.
The intensity dependent amplitude change (IDAP) of auditory evoked Event Related Potential (ERP) components has been found to correlate with the level of central serotonergic neurotransmission and to be associated with response to certain antidepressants. However, it is currently unknown whether there is a general abnormality of the IDAP in patients with major depression. Therefore, the purpose of the present study was to compare the IDAP in unmedicated depressed patients with that of healthy control subjects.
We report the results of a study evaluating the change of auditory evoked P1, N1, P2 as well as P1/N1 and N1/P2 peak to peak amplitudes in 34 in-patients with major depressive episode prior to antidepressant treatment, and 44 healthy control subjects. Clinical symptoms of depression were assessed by means of standardized psychiatric rating scales (CGI, HDRS, HAMA and BDI).
In multivariate analyses of variance we found no group differences in the intensity dependent increase neither of the P1, N1, and P2 nor of the P1/N1 and N1/P2 peak to peak amplitudes between patients and controls.
Our data revealed no general abnormality of the IDAP in patients with major depression in comparison to healthy control subjects. This result suggests that specific alterations of the IDAP are not to be expected in major depression in general, these may be confined to subgroups of depressed patients.
听觉诱发电位（ERP）成分的强度依赖性幅度变化（IDAP）已被发现与中枢5-羟色胺能神经传递水平相关，并与对某些抗抑郁药的反应有关。然而，目前尚不清楚重度抑郁症患者的IDAP是否存在普遍异常。因此，本研究的目的是比较未接受药物治疗的抑郁症患者与健康对照者的IDAP。
我们报告了一项研究结果，该研究评估了34例抗抑郁治疗前的重度抑郁发作住院患者和44例健康对照者的听觉诱发电位P1、N1、P2以及P1/N1和N1/P2峰峰值幅度的变化。通过标准化精神科评定量表（CGI、HDRS、HAMA和BDI）评估抑郁的临床症状。
在多变量方差分析中，我们发现患者和对照组之间在P1、N1和P2以及P1/N1和N1/P2峰峰值幅度的强度依赖性增加方面没有组间差异。
我们的数据显示，与健康对照者相比，重度抑郁症患者的IDAP没有普遍异常。这一结果表明，一般而言，重度抑郁症患者的IDAP不会出现特定改变；这些改变可能局限于抑郁症患者的亚组。
