Linka Thomas, Sartory Gudrun, Gastpar Markus, Scherbaum Norbert, Müller Bernhard W
Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Psychiatry Res. 2009 Sep 30;169(2):139-43. doi: 10.1016/j.psychres.2008.06.009. Epub 2009 Aug 22.
The intensity (loudness) dependent amplitude change (IDAP) of the auditory event-related potential (ERP) has been shown to be associated with the outcome of treatment with selective serotonin reuptake inhibitors in major depression. The purpose of the present study is to evaluate associations between clinical symptoms of major depression and the IDAP as an indirect indicator of cortical serotonergic function. We assessed 40 in-patients suffering from a major depressive episode (DSM-IV) prior to antidepressant treatment. Psychometric characteristics of depression were assessed by means of psychiatric rating scales (CGI, HDRS, HAMA, STAI and BDI) and evaluated for associations with auditory evoked P1, N1, P2 as well as P1/N1 and N1/P2 peak to peak amplitude slopes. Our data revealed a positive correlation of the intensity dependent N1 amplitude slope with the degree of certain somatic symptoms of depression: loss of appetite and weight, insomnia, and sexual dysfunction. The results of our study might contribute to a more specific clinical basis in the differential indication of serotonergic versus noradrenergic antidepressants.
听觉事件相关电位（ERP）的强度（响度）依赖性振幅变化（IDAP）已被证明与重度抑郁症患者使用选择性5-羟色胺再摄取抑制剂的治疗结果相关。本研究的目的是评估重度抑郁症的临床症状与作为皮质5-羟色胺能功能间接指标的IDAP之间的关联。我们评估了40例在接受抗抑郁治疗前患有重度抑郁发作（DSM-IV）的住院患者。通过精神科评定量表（CGI、HDRS、HAMA、STAI和BDI）评估抑郁症的心理测量特征，并评估其与听觉诱发的P1、N1、P2以及P1/N1和N1/P2峰峰值振幅斜率的关联。我们的数据显示，强度依赖性N1振幅斜率与抑郁症某些躯体症状的程度呈正相关：食欲和体重下降、失眠以及性功能障碍。我们的研究结果可能有助于为5-羟色胺能与去甲肾上腺素能抗抑郁药的差异适应症提供更具体的临床依据。
