Sundqvist A, Berg M, Moreno-López J, Linné T
Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala.
Arch Virol. 1992;122(3-4):331-40. doi: 10.1007/BF01317194.
The complete nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene of the porcine paramyxovirus LPMV, was determined from cDNA derived from viral genomic RNA. The gene was 1906 nucleotides long including a putative gene end and poly A signal. One long open reading frame was found encoding a protein of 576 amino acids with a calculated molecular weight of 63,324. The protein contains four potential N-glycosylation sites and a major hydrophobic region near the N-terminal, suggesting a membrane anchor domain. Comparison of the deduced amino acid sequence of the LPMV HN protein with that of other paramyxovirus HN proteins, revealed the highest amino acid identity to simian virus 5 of 43% and mumps virus of 41%.
从猪副粘病毒LPMV的病毒基因组RNA衍生的cDNA中确定了血凝素-神经氨酸酶（HN）基因的完整核苷酸序列。该基因长1906个核苷酸，包括一个推定的基因末端和多聚腺苷酸信号。发现一个长开放阅读框编码一个576个氨基酸的蛋白质，计算分子量为63324。该蛋白质含有四个潜在的N-糖基化位点和靠近N端的一个主要疏水区域，提示有一个膜锚定结构域。将LPMV HN蛋白的推导氨基酸序列与其他副粘病毒HN蛋白的序列进行比较，发现与猿猴病毒5的氨基酸同一性最高，为43%，与腮腺炎病毒的氨基酸同一性为41%。
