An update on the management of Wilms' tumour.
作者信息
Ahmed H U, Arya M, Tsiouris A, Sellaturay S V, Shergill I S, Duffy P G, Mushtaq I
机构信息
Great Ormond Street Hospital for Sick Children, Great Ormond Street, London, United Kingdom.
出版信息
Eur J Surg Oncol. 2007 Sep;33(7):824-31. doi: 10.1016/j.ejso.2006.12.013. Epub 2007 Feb 20.
AIMS
To review the management of Wilms' tumour.
METHODS
A search of the literature was performed using the PubMed database (1966 to May 2006) with the search terms 'Wilms' and either 'tumour/tumor' or 'cancer' or 'carcinoma'. This was augmented by manual searches of publications.
FINDINGS
The success of clinical trials in Wilms' tumour patients over the past 30 years has led to an overall survival of 85% and the introduction of less aggressive chemotherapeutic regimes for patients. Large randomised controlled trials have been published on the management of Wilms' tumour by various collaborative groups, including the National Wilms' Tumour Study Group (NWTSG) in North America and the Société Internationale d'Oncologie Pédiatrique (SIOP) plus the United Kingdom Children's Cancer Study Group (UKCCSG) in Europe.
CONCLUSIONS
Controversy exists as to the best approach to the management of these children with regard to neoadjuvant chemotherapy. Challenges remain in the identification of histological and molecular risk factors for the stratification of treatment intensity.
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