Zahir Mazyar, Alidousti Arash, Kajbafzadeh Abdol-Mohammad, Arshadi Hamid, Kompani Farzad, Hajivalizadeh Sepideh, Zolbin Masoumeh Majidi, Ghohestani Seyed Mohammad, Amirzargar Hossein, Hekmati Pooya
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences.
Department of Pediatric Urology, Pediatric Urology and Regenerative Medicine Research Center.
Ann Med Surg (Lond). 2023 Apr 18;85(5):1425-1429. doi: 10.1097/MS9.0000000000000671. eCollection 2023 May.
Wilms tumor (WT) is among the most common pediatric malignancies. In this study, the authors tried to evaluate the adherence to internationally-approved WT treatment protocols in our tertiary medical center in Iran.
In this retrospective study, the medical records of 72 pathologically confirmed WT patients who underwent treatment from April 2014 to February 2020 were evaluated. Demographic characteristics, histologic features of the tumors and metastases, utilized treatments, and survival rates were subsequently investigated.
From the total of 72 patients, 31 (43.1%) and 41 (56.9%) were males and females, respectively. The median age at the time of diagnosis was 44.0 (interquartile range: 18.5, 72.0) months. Among the patients, favorable histology was observed in 68 (94.6%) patients, while 4 (5.4%) patients had unfavorable histology. Regarding chemotherapy, 34/56 (60.7%), 4/56 (7.1%), and 18/56 (32.2%) received adjuvant, neoadjuvant, and combined chemotherapy, respectively. The mean numbers of neoadjuvant and adjuvant chemotherapy sessions were 9.4±5.6 and 14.5±11.1, respectively. 32/72 (44.4%) of the patients received adjuvant radiotherapy with a mean number of 7.3±3.6 sessions. Overall survival rates were 86% at 1-year, 74% at 3-year, and 62% at 5-year.
Our results suggested that while the demographic characteristics of WT patients in Iran resemble those in other countries, abidance to internationally recommended protocols is relatively low. Moreover, survival rates were rather dismal in our study compared to those from other developing countries, further signifying the need for the development of a nation-specific treatment protocol for WT.
肾母细胞瘤（WT）是最常见的儿科恶性肿瘤之一。在本研究中，作者试图评估伊朗一家三级医疗中心对国际认可的WT治疗方案的依从性。
在这项回顾性研究中，对2014年4月至2020年2月期间接受治疗的72例经病理确诊的WT患者的病历进行了评估。随后调查了人口统计学特征、肿瘤和转移灶的组织学特征、采用的治疗方法以及生存率。
在总共72例患者中，男性31例（43.1%），女性41例（56.9%）。诊断时的中位年龄为44.0（四分位间距：18.5，72.0）个月。在患者中，68例（94.6%）观察到良好的组织学，而4例（5.4%）患者组织学不良。关于化疗，56例中有34例（60.7%）、4例（7.1%）和18例（32.2%）分别接受了辅助化疗、新辅助化疗和联合化疗。新辅助化疗和辅助化疗的平均疗程数分别为9.4±5.6和14.5±11.1。72例患者中有32例（44.4%）接受了辅助放疗，平均疗程数为7.3±3.6次。1年总生存率为86%，3年为74%，5年为62%。
我们的结果表明，虽然伊朗WT患者的人口统计学特征与其他国家相似，但对国际推荐方案的依从性相对较低。此外，与其他发展中国家相比，我们研究中的生存率相当低，这进一步表明需要制定针对WT的国家特定治疗方案。
