佩吉特病：当前概念

Paget's disease: current concepts.

作者信息

Posen S

机构信息

Department of Medicine, University of Sydney, New South Wales, Australia.

出版信息

Aust N Z J Surg. 1992 Jan;62(1):17-23. doi: 10.1111/j.1445-2197.1992.tb05349.x.

DOI:10.1111/j.1445-2197.1992.tb05349.x

PMID:1731733

Abstract

The curious geographic variations in the prevalence of Paget's disease remain unexplained and the viral hypothesis remains unproved. An association between transient hyperphosphataemia of infancy and subsequent Paget's disease has not been established. Some 5% of Pagetic patients have hyperparathyroidism although the mechanism of this apparent association remains unknown. Several agents are available for the medical treatment of Paget's disease but there is a lack of consensus concerning therapeutic aims.

摘要

佩吉特病患病率存在奇特的地理差异，其原因尚不明，病毒假说也未得到证实。婴儿期短暂高磷血症与后续佩吉特病之间的关联尚未确立。约5%的佩吉特病患者患有甲状旁腺功能亢进，尽管这种明显关联的机制尚不清楚。有几种药物可用于佩吉特病的医学治疗，但在治疗目标方面缺乏共识。