Bakri Sophie J, Kitzmann Anna S
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Am J Ophthalmol. 2007 Mar;143(3):505-7. doi: 10.1016/j.ajo.2006.11.047. Epub 2006 Dec 28.
To report two cases of a retinal pigment epithelial (RPE) tear after intravitreal injection of 0.05 mg ranibizumab.
Observational case report.
Two patients with choroidal neovascularization (CNV) resulting from age-related macular degeneration (AMD) were treated with an intravitreal injection of ranibizumab.
Both patients were found to have a RPE tear on follow-up visits at one month, confirmed by optical coherence tomography (OCT) and by fluorescein or indocyanine green angiography.
RPE tears may occur after intravitreal injection of ranibizumab. Further study is needed to determine whether CNV membranes associated with pigment epithelial detachments (PED) are more likely to develop RPE tears after treatment with anti-vascular endothelial growth factor (anti-VEGF) agents.
报告两例玻璃体内注射0.05毫克雷珠单抗后发生视网膜色素上皮（RPE）撕裂的病例。
观察性病例报告。
两名因年龄相关性黄斑变性（AMD）导致脉络膜新生血管（CNV）的患者接受了玻璃体内注射雷珠单抗治疗。
两名患者在1个月的随访中均被发现有RPE撕裂，经光学相干断层扫描（OCT）以及荧光素或吲哚菁绿血管造影证实。
玻璃体内注射雷珠单抗后可能发生RPE撕裂。需要进一步研究以确定与色素上皮脱离（PED）相关的CNV膜在用抗血管内皮生长因子（抗VEGF）药物治疗后是否更易发生RPE撕裂。
