Smith Lynnelle K, Kurz Paul A, Wilson David J, Flaxel Christina J, Rosenbaum James T
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.
Am J Ophthalmol. 2007 Mar;143(3):536-8. doi: 10.1016/j.ajo.2006.10.040. Epub 2006 Nov 28.
To present two patients with prior unilateral, herpetic keratitis who developed acute retinal necrosis (ARN) in the contralateral eye. These cases have noticeable similarities to the von Szily reaction. This describes the development of a contralateral retinitis subsequent to an anterior chamber injection of herpes simplex virus (HSV).
Interventional case series.
Retrospective chart and literature review.
The first patient had neonatally acquired herpetic keratitis and developed ARN at age 21. Polymerase chain reaction of a vitreous biopsy detected HSV type-2 (HSV-2). The second patient was clinically diagnosed with ARN contralateral to varicella zoster keratitis. A detailed literature search located seven prior case reports with a von Szily reaction. These resembled our two cases except none had HSV-2 or years of latency from keratitis to retinitis.
Clinicians need to be cognizant of the von Szily reaction.
介绍两名曾患单侧疱疹性角膜炎的患者，其对侧眼发生了急性视网膜坏死（ARN）。这些病例与冯·西利反应有明显相似之处。该反应描述的是在前房注射单纯疱疹病毒（HSV）后对侧视网膜发生的炎症。
干预性病例系列。
回顾性病历及文献综述。
首例患者新生儿期患疱疹性角膜炎，21岁时发生ARN。玻璃体活检的聚合酶链反应检测到2型单纯疱疹病毒（HSV-2）。第二例患者临床诊断为水痘带状疱疹性角膜炎对侧的ARN。详细的文献检索发现了7例先前有冯·西利反应的病例报告。这些病例与我们的两例相似，但均无HSV-2，也没有从角膜炎到视网膜炎症的数年潜伏期。
临床医生需要认识到冯·西利反应。
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