唐氏综合征患者血浆中的氧化型低密度脂蛋白（oxLDL）和过氧化物。
Oxidated low-density lipoproteins (oxLDL) and peroxides in plasma of Down syndrome patients.
作者信息
Licastro F, Dogliotti G, Goi G, Malavazos A E, Chiappelli M, Corsi M M
机构信息
Department of Experimental Pathology, Laboratory of Immunology, University of Bologna, Bologna, Italy.
出版信息
Arch Gerontol Geriatr. 2007;44 Suppl 1:225-32. doi: 10.1016/j.archger.2007.01.031.
A low prevalence of coronary artery disease is usually observed in adult Down syndrome (DS) subjects, and these patients rarely die because of atherosclerotic complications. High levels of oxLDL were found in plasma from children and adults with DS. Plasma oxLDL were still increased in elderly with DS, however, difference with controls was not statistically significant. Concentrations of plasma peroxides were significantly higher in children and adults with DS than controls. No differences between elderly DS subjects and controls were present. We speculated that increased levels of protective antiathero-sclerosis factors might be produced in young and adult DS subjects and these may explain low incidence of cardiovascular diseases in the syndrome. Up-regulation of vascular andothelial growth factor (VEGF)-mediated signals and increased nerve growth factor (NGF) expression might be two of these important protective factors.
通常在成年唐氏综合征（DS）患者中观察到冠状动脉疾病的低患病率，并且这些患者很少因动脉粥样硬化并发症而死亡。在患有DS的儿童和成人的血浆中发现了高水平的氧化低密度脂蛋白（oxLDL）。然而，老年DS患者的血浆oxLDL仍然升高，但与对照组的差异无统计学意义。患有DS的儿童和成人的血浆过氧化物浓度显著高于对照组。老年DS患者与对照组之间没有差异。我们推测，年轻和成年DS患者可能产生了更多的保护性抗动脉粥样硬化因子，这可能解释了该综合征中心血管疾病的低发病率。血管内皮生长因子（VEGF）介导的信号上调和神经生长因子（NGF）表达增加可能是其中两个重要的保护因子。
Zotero 插件