Rouhani Panta, Fleming Lora E, Frías Jaime, Martínez-Frías María Luisa, Bermejo Eva, Mendioroz Jacobo
Department of Epidemiology & Public Health, University of Miami Miller School of Medicine, Suite 200, Miami, FL 33136, USA.
Matern Child Health J. 2007 Jul;11(4):403-5. doi: 10.1007/s10995-007-0186-3. Epub 2007 Feb 21.
Research has indicated that the appropriate intake of folic acid, a B vitamin, before and during early pregnancy has been shown to prevent 50-70% of neural-tube defects. Increased NTD incidence has long been reported to occur more frequently among women of lower socioeconomic (SES). Since consumption of the folate-rich Mediterranean diet in Spain does not vary by socio-economic status (SES), we hypothesized that there would be no social class effect on NTD occurrence. Using data from a Spanish hospital-based birth defects registry, we studied the risk of Neural Tube Defects (NTDs) in 980 cases and 774 controls between 1980 and 2003. Our analysis showed that the risk of NTDs did not vary by SES. This finding suggests that increased access to folate and nutrition education might benefit women of lower SES in the US.
研究表明，在怀孕早期之前及期间适当摄入叶酸（一种B族维生素）可预防50%至70%的神经管缺陷。长期以来，据报道神经管缺陷发生率在社会经济地位较低的女性中更为常见。由于西班牙富含叶酸的地中海饮食的摄入量并不因社会经济地位而有所不同，我们推测社会阶层对神经管缺陷的发生没有影响。利用西班牙一家医院出生缺陷登记处的数据，我们研究了1980年至2003年间980例病例和774例对照中神经管缺陷（NTDs）的风险。我们的分析表明，神经管缺陷的风险并不因社会经济地位而有所不同。这一发现表明，增加叶酸的获取和营养教育可能会使美国社会经济地位较低的女性受益。
