Lester Kristin, Stepleman Lara, Hughes Mary
Department of Psychiatry and Health Behavior, Augusta, GA, USA.
J Behav Med. 2007 Apr;30(2):177-86. doi: 10.1007/s10865-007-9095-6. Epub 2007 Feb 23.
Within the multiple sclerosis (MS) population, high prevalence of psychiatric concerns, such as depression and anxiety, has been well documented. The purpose of this study was to examine factors contributing to higher depression and anxiety levels in a sample of 82 patients utilizing MS clinic services. Independent variables included MS physical severity, self-reported cognitive impairment, and perceived illness management, respectively. Results from hierarchical regression analyses indicated that depression was related to the physical severity, self-reported cognitive impairment, and perceived illness management variables. Anxiety was also related to the physical severity and self-reported cognitive impairment variables but not to the perceived illness management ones, suggesting that depression and anxiety symptoms may involve somewhat different processes within MS. The findings of this study support further clinical consideration and additional investigation of these variables in the treatment of anxiety and depression in an MS clinic population.
在多发性硬化症（MS）患者群体中，诸如抑郁和焦虑等精神问题的高患病率已有充分记录。本研究的目的是在82名使用MS诊所服务的患者样本中，考察导致抑郁和焦虑水平较高的因素。自变量分别包括MS身体严重程度、自我报告的认知障碍和感知到的疾病管理。分层回归分析结果表明，抑郁与身体严重程度、自我报告的认知障碍以及感知到的疾病管理变量有关。焦虑也与身体严重程度和自我报告的认知障碍变量有关，但与感知到的疾病管理变量无关，这表明抑郁和焦虑症状在MS中可能涉及略有不同的过程。本研究结果支持在MS诊所人群中治疗焦虑和抑郁时，对这些变量进行进一步的临床考虑和额外研究。
