Iannetti Giorgio, Torroni Andrea, Chiummariello Stefano, Cavallotti Carlo
Maxillo-Facial Surgery Unit, Medical Faculty, University La Sapienza Rome, Italy.
Head Face Med. 2007 Feb 23;3:12. doi: 10.1186/1746-160X-3-12.
Haemangiomas of the head or face are a frequent vascular pathology, consisting in an embryonic dysplasia that involves the cranial-facial vascular network. Haemangiomas show clinical, morphological, developmental and structural changes during their course.
The clinical characteristics of head-facial haemagiomas were studied in 28 individuals (9 males and 19 females) admitted in our Hospital. Sixteen of these patients(n = 16) underwent surgery for the removal of the haemangiomas. All the removed tissues were transferred in experimental laboratories for the staining of microanatomical details, somatic and visceral nerve fibres, adrenergic and catecholaminergic nerve fibres. Beta-adrenergic receptors were died with a fluorescent method. All results were submitted to the quantitative analysis of images and statistical evaluation of the data.
The morphological results revealed numerous micro-anatomical characteristics of the haemangiomatous vessels. The somatic and visceral nerve fibres were poor and located exclusively in the adventitial layer. There was a marked decrease of adrenergic nerve fibres in the haemangiomatous vessels. The fluorescence of catecholaminergic nerve fibres and the overall area of fluorescent structures were also decreased in haemangiomatous vessels. Beta adrenergic receptors are strongly decreased in haemangiomatous vessels. The morphometrical analysis of images and statistical evaluation of the data confirmed all our experimental results.
The catecholaminergic innervation of the human haemangiomatous vessels comprises nerve fibres containing the main catecholaminergic neurotransmitters that are sympathetic in nature. These neurotransmitters are closely related to beta-adrenergic receptors. The sympathetic nervous system plays a key role in the control of the vascular bed flow and vascular motility in both normal and haemangiomatous vessels.
头面部血管瘤是一种常见的血管病变，由涉及颅面部血管网络的胚胎发育异常组成。血管瘤在其病程中表现出临床、形态、发育和结构变化。
对我院收治的28例患者（9例男性，19例女性）的头面部血管瘤临床特征进行了研究。其中16例患者（n = 16）接受了血管瘤切除术。所有切除的组织均转移至实验实验室，用于微解剖细节、躯体和内脏神经纤维、肾上腺素能和儿茶酚胺能神经纤维的染色。采用荧光法对β-肾上腺素能受体进行染色。所有结果均进行图像定量分析和数据统计评估。
形态学结果显示血管瘤血管有许多微解剖特征。躯体和内脏神经纤维较少，仅位于外膜层。血管瘤血管中肾上腺素能神经纤维明显减少。血管瘤血管中儿茶酚胺能神经纤维的荧光及荧光结构的总面积也减少。血管瘤血管中β-肾上腺素能受体明显减少。图像的形态计量分析和数据的统计评估证实了我们所有的实验结果。
人类血管瘤血管的儿茶酚胺能神经支配包括含有主要儿茶酚胺能神经递质的神经纤维，这些神经递质本质上是交感神经的。这些神经递质与β-肾上腺素能受体密切相关。交感神经系统在正常血管和血管瘤血管的血管床血流和血管运动控制中起关键作用。
