Bhatti Zahida, Berenson Charles S
Infectious Disease Division, VA Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, New York 14215, USA.
BMC Infect Dis. 2007 Feb 23;7:8. doi: 10.1186/1471-2334-7-8.
We describe the first case of systemic cat scratch disease in a patient receiving peginterferon alpha-2a and ribavirin for treatment of hepatitis C. Cases of adult systemic CSD are extremely infrequent and immunomodulatory treatment for hepatitis C has been associated with aberrant host responses to common pathogens.
A 52 year old man being treated for hepatitis C presented with diffuse lymphadenopathy, weight loss, fevers and splenic lesions. Symptoms were initially confused with adverse effects of his regimen, delaying recognition of his infection. Diagnostic investigation, including histopathology, microbiology and serologic parameters, confirmed that his illness was due to disseminated cat scratch disease with Bartonella henselae.
Disseminated CSD is exceptionally rare in adults. We describe the first case of disseminated cat scratch disease associated with peginterferon alpha and ribavirin to alert clinicians of the need to be aware of unusual manifestations of common infections in this population.
我们描述了首例在接受聚乙二醇干扰素α-2a和利巴韦林治疗丙型肝炎的患者中发生的系统性猫抓病。成人系统性猫抓病病例极为罕见，而丙型肝炎的免疫调节治疗与宿主对常见病原体的异常反应有关。
一名正在接受丙型肝炎治疗的52岁男性出现弥漫性淋巴结病、体重减轻、发热和脾脏病变。症状最初被误诊为其治疗方案的不良反应，从而延误了对感染的诊断。包括组织病理学、微生物学和血清学参数在内的诊断性检查证实，他的疾病是由巴尔通体属汉赛巴尔通体引起的播散性猫抓病。
播散性猫抓病在成人中极为罕见。我们描述了首例与聚乙二醇干扰素α和利巴韦林相关的播散性猫抓病病例，以提醒临床医生需要注意该人群中常见感染的不寻常表现。
