Rottenberg Jonathan, Chambers Andrea S, Allen John J B, Manber Rachel
Mood and Emotion Laboratory, Department of Psychology, University of South Florida, PCD 4118G, 4202 E. Fowler Avenue, Tampa, FL 33620-7200, United States.
J Affect Disord. 2007 Nov;103(1-3):173-9. doi: 10.1016/j.jad.2007.01.028. Epub 2007 Feb 22.
Impaired cardiac vagal control (CVC), as indexed by respiratory sinus arrhythmia, has been investigated as a risk factor for major depressive disorder (MDD), but prior findings are mixed with respect to whether impaired CVC predicts greater global depression severity and/or a more severe course of disorder. One possible explanation for mixed findings is that CVC abnormalities in MDD are related more closely to specific depression symptoms than to the syndrome as a whole.
Depression severity (both global and symptom-specific indices) and electrocardiogram measures of resting CVC were obtained from 151 diagnosed MDD participants at intake, before randomization to a novel treatment for depression (acupuncture), and again after 8 and 16 weeks.
Resting CVC did not predict global indices of depression in cross-sectional or longitudinal analyses. In symptom-specific analyses, resting CVC was positively related to sad mood and crying and inversely related to middle and late insomnia. Improvement in late insomnia was related to increases in CVC over time.
Relationships between CVC and MDD were studied only within the clinical range of severity. Symptom analyses were exploratory and hence did not correct for Type I error.
Resting CVC did not exhibit concurrent or prospective relations with overall depression severity but a few specific symptoms did. Symptomatic heterogeneity across samples may account for mixed findings within the CVC-depression literature.
以呼吸性窦性心律不齐为指标的心脏迷走神经控制（CVC）受损已被作为重度抑郁症（MDD）的一个风险因素进行研究，但先前的研究结果在CVC受损是否预示着更严重的整体抑郁严重程度和/或更严重的病程方面存在分歧。研究结果存在分歧的一个可能解释是，MDD中的CVC异常与特定的抑郁症状关系更为密切，而非与整个综合征相关。
从151名已确诊的MDD参与者在入组时、随机接受一种新型抑郁症治疗（针灸）之前以及8周和16周后获取抑郁严重程度（包括整体和特定症状指标）以及静息CVC的心电图测量值。
在横断面或纵向分析中，静息CVC均不能预测抑郁的整体指标。在特定症状分析中，静息CVC与悲伤情绪和哭泣呈正相关，与中晚期失眠呈负相关。晚期失眠的改善与CVC随时间的增加有关。
仅在严重程度的临床范围内研究了CVC与MDD之间的关系。症状分析是探索性的，因此未对I型错误进行校正。
静息CVC与整体抑郁严重程度没有同时或前瞻性的关系，但与一些特定症状有关。样本间症状的异质性可能解释了CVC-抑郁症文献中的研究结果分歧。
