韩国普通人群中抑郁症与心血管疾病风险之间的关联：2016年韩国国民健康与营养检查调查结果
Association between depression and cardiovascular disease risk in general population of Korea: results from the Korea National Health and Nutrition Examination Survey, 2016.
作者信息
Song Jinho, Koh Tae Hwan, Park One, Kwon Daeil, Kang Seonghoon, Kwak Kyeongmin, Park Jong-Tae
机构信息
Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, Ansan, Korea.
Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea.
出版信息
Ann Occup Environ Med. 2019 Jun 20;31:e10. doi: 10.35371/aoem.2019.31.e10. eCollection 2019.
BACKGROUND
Depression is considered as a risk factor for cardiovascular disease (CVD) and associated with changes in individuals' health status that might influence CVD risk. However, most studies have scrutinized this relationship on a rather narrower and specific study population. By focusing on general population of Korea, we sought to inspect the association of depression with CVD risk and cardiovascular risk factors.
METHODS
The data from the first year (2016) of the 7th Korea National Health and Nutrition Examination Survey was used. Participants were classified by the Patient Health Questionnaire-9 (PHQ-9) score as such: normal group (PHQ-9 score 0-4), mild depression (MD) group (PHQ-9 score 5-9) and moderate and severe depression (MSD) group (PHQ-9 score 10-27). General linear model was used to analyze differences and the trend of mean CVD risk according to depression level. Adjusted odds ratios (AORs) were calculated by logistic regression to identify the association between depression and cardiovascular risk factors after adjusting for age.
RESULTS
Mean CVD risk of MSD group was higher than that of normal group ( < 0.05). There was a tendency of CVD risk to increase as depression worsened ( < 0.01). Among men, MSD group was associated with current smoking (AOR, 2.97; 95% confidence interval [CI], 1.78-4.97), taking antihypertensive medications (AOR, 2.42; 95% CI, 1.26-4.66), increased fasting blood sugar (> 125 mg/dL; AOR, 2.37; 95% CI, 1.25-4.50) and taking diabetes medications (AOR, 3.08; 95% CI, 1.65-5.72). MD group was associated with current smoking (AOR, 1.60; 95% CI, 1.18-2.17). Among women, MSD group was associated with high body mass index (≥ 25 kg/m; AOR, 1.61; 95% CI, 1.11-2.32), large waist circumference (≥ 85 cm; AOR, 1.63; 95% CI, 1.12-2.37), current smoking (AOR, 5.11; 95% CI, 3.07-8.52) and taking diabetes medications (AOR, 2.62; 95% CI, 1.68-4.08). MD group was associated with current smoking (AOR, 1.86; 95% CI, 1.18-2.93).
CONCLUSIONS
We suggest that depression is associated with increased risk for CVD occurrence in general population of Korea.
背景
抑郁症被认为是心血管疾病（CVD）的一个风险因素，并且与可能影响CVD风险的个体健康状况变化相关。然而，大多数研究在相当狭窄和特定的研究人群中仔细研究了这种关系。通过关注韩国的普通人群，我们试图考察抑郁症与CVD风险及心血管危险因素之间的关联。
方法
使用了韩国第七次全国健康与营养检查调查第一年（2016年）的数据。参与者根据患者健康问卷-9（PHQ-9）评分进行如下分类：正常组（PHQ-9评分0-4）、轻度抑郁症（MD）组（PHQ-9评分5-9）和中度及重度抑郁症（MSD）组（PHQ-9评分10-27）。采用一般线性模型分析根据抑郁水平的平均CVD风险差异及趋势。通过逻辑回归计算调整后的优势比（AOR），以确定在调整年龄后抑郁症与心血管危险因素之间的关联。
结果
MSD组的平均CVD风险高于正常组（P<0.05）。随着抑郁症病情加重，CVD风险有增加的趋势（P<0.01）。在男性中，MSD组与当前吸烟（AOR，2.97；95%置信区间[CI]，1.78-4.97）、服用降压药（AOR，2.42；95%CI，1.26-4.66）、空腹血糖升高（>125mg/dL；AOR，2.37；95%CI，1.25-4.50）及服用糖尿病药物（AOR，3.08；95%CI，1.65-5.72）相关。MD组与当前吸烟（AOR，1.60；95%CI，1.18-2.17）相关。在女性中，MSD组与高体重指数（≥25kg/m²；AOR，1.61；95%CI，1.11-2.32）、大腰围（≥85cm；AOR，1.63；95%CI，1.12-2.37）、当前吸烟（AOR，5.11；95%CI，3.07-8.52）及服用糖尿病药物（AOR，2.62；95%CI，1.68-4.08）相关。MD组与当前吸烟（AOR，1.86；95%CI，1.18-2.93）相关。
结论
我们认为抑郁症与韩国普通人群中CVD发生风险增加相关。
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