Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Epidemiol Health. 2011;33:e2011007. doi: 10.4178/epih/e2011007. Epub 2011 Aug 20.
Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.
The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.
WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.
These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.
脂联素与西方人群的糖尿病密切相关。然而，在非肥胖人群中，脂联素是否与空腹血糖受损（IFG）独立相关尚不清楚。
测量了 27549 名健康韩国人的血清脂联素、胰岛素抵抗（IR）和腰围（WC）。然后根据性别将个体分为三分位组。IFG 定义为空腹血清葡萄糖为 100-125mg/dL 且无糖尿病。使用稳态模型评估的胰岛素抵抗（HOMA-IR）计算 IR。使用逻辑回归分析确定脂联素与 IFG 的相关性。
WC 和脂联素与男性和女性的 IFG 均相关。然而，在调整 HOMA-IR 后，WC 与 IFG 的相关性在男性和女性中均减弱。在男性和女性中，调整 HOMA-IR 并分层后，脂联素仍与 IFG 相关。IR 和脂联素与 IFG 的强联合相关性在男性和女性中均可见。在 IR 最高三分位和脂联素最低三分位的人群中，多变量校正后的比值比（OR）（95%置信区间[CI]）为男性 9.8（7.96 至 12.07），女性 24.1（13.86 至 41.94）。
这些结果表明脂联素与 IFG 密切相关，并指出脂联素是糖尿病非人群 IFG 的另一个诊断生物标志物。
