染色质在转录过程中的作用。

The role of chromatin during transcription.

作者信息

Li Bing, Carey Michael, Workman Jerry L

机构信息

Stowers Medical Research Institute, 1000 East 50(th) Street, Kansas City, MO 64110, USA.

出版信息

Cell. 2007 Feb 23;128(4):707-19. doi: 10.1016/j.cell.2007.01.015.

DOI:10.1016/j.cell.2007.01.015

PMID:17320508

Abstract

Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.

摘要

染色质结构对由RNA聚合酶II介导的转录的各个方面都构成了重大障碍。染色质结构的动态变化通过多种机制受到严格调控，包括组蛋白修饰、染色质重塑、组蛋白变体掺入和组蛋白去除。在本综述中，我们重点介绍了我们对染色质调控理解的进展，并讨论了这种调控如何影响转录因子的结合以及转录的起始和延伸步骤。