p63在牙源性囊肿中的表达。

p63 expression in odontogenic cysts.

作者信息

Lo Muzio L, Santarelli A, Caltabiano R, Rubini C, Pieramici T, Fior A, Trevisiol L, Carinci F, Leonardi R, Bufo P, Lanzafame S, Piattelli A

机构信息

Department of Surgical Sciences, University of Foggia, Foggia, Italy.

出版信息

Int J Oral Maxillofac Surg. 2005 Sep;34(6):668-73. doi: 10.1016/j.ijom.2004.12.002.

DOI:10.1016/j.ijom.2004.12.002

PMID:16053892

Abstract

A total of 123 cases of odontogenic cysts, distributed as follows: 30 follicular (FC), 35 radicular (RC), 53 keratocysts, 1 glandular odontogenic and 4 calcifying odontogenic cysts, were analysed by immunohistochemistry for expression of p63, a component of p53 protein family. In RCs p63 positivity was not only in basal and parabasal layers but also in the intermediate layer and about 1/3 of cases displayed a percentage of stained cells comprised between 0 and <5%, and about 2/3 between >5% and <50%. In FCs positivity was confined to basal and parabasal layers of the epithelium and in the majority of FCs the stained cells were comprised between 0 and <5%. OKCs displayed the most intense and diffuse p63 labeling. In conclusion, these data suggest that p63 expression may be useful to identify cysts type with more aggressive and invasive phenotype supporting the hypothesis of a suprabasal proliferative compartment in OKCs.

摘要

共对123例牙源性囊肿进行了分析，其分布如下：30例滤泡囊肿（FC）、35例根端囊肿（RC）、53例角化囊肿、1例腺牙源性囊肿和4例牙源性钙化囊肿，通过免疫组织化学检测p63（p53蛋白家族的一个成分）的表达。在根端囊肿中，p63阳性不仅见于基底层和副基底层，也见于中间层，约1/3的病例染色细胞百分比在0至<5%之间，约2/3在>5%至<50%之间。在滤泡囊肿中，阳性局限于上皮的基底层和副基底层，大多数滤泡囊肿中染色细胞在0至<5%之间。角化囊肿型牙源性囊肿（OKC）显示出最强且最弥漫的p63标记。总之，这些数据表明p63表达可能有助于识别具有更具侵袭性表型的囊肿类型，支持角化囊肿型牙源性囊肿存在基底层以上增殖区室的假说。