Patil Namrata N, Wadhwan Vijay, Chaudhary Minal, Nayyar Abhishek Singh
Department of Oral Pathology and Microbiology, Saraswati Dhanwantari Dental College and Hospital and Post Graduate Research Institute, Parbhani, Maharashtra, India.
Department of Oral Pathology and Microbiology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India.
J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):384-389. doi: 10.4103/0973-029X.190908.
KAI-1/CD82 is a tumor suppressor gene with decreased gene expression being associated with increased invasive ability of oral squamous cell carcinomas (OSCCs). p53 protein functions in the G1-S phase of the cell cycle to allow repair of damaged DNA. In the present study, p53 and KAI-1 expression was investigated using monoclonal antibodies in OSCC.
The aim of this study was to detect KAI-1 and p53 expression in OSCCs and to assess the relation between both in OSCCs.
The present study included histopathologically diagnosed thirty cases of well- and moderately differentiated OSCCs to study the expression of KAI-1 and p53 antibodies.
The results obtained were tabulated and statistically analyzed using descriptive statistical analysis; one-way ANOVA; least square difference method and independent -test.
OSCCs exhibited 41.62% positivity for KAI-1 while p53 positive cells were recorded to an extent of 60.82%. A significant positive correlation was observed between KAI-1 and p53 expression in OSCCs.
Although a significant amount of work is still required to uncover the mechanisms of action and regulation of KAI-1 and p53 expression, control of the complex metastatic processes would be of interest in controlling the tumor biology in OSCCs as well as other types of malignancies to enhance prognosis in the affected patients and to help protect against future metastasis in the going to be treated and treated patients.
KAI-1/CD82是一种肿瘤抑制基因，其基因表达降低与口腔鳞状细胞癌（OSCC）侵袭能力增强有关。p53蛋白在细胞周期的G1-S期发挥作用，以修复受损的DNA。在本研究中，使用单克隆抗体对OSCC中的p53和KAI-1表达进行了研究。
本研究的目的是检测OSCC中KAI-1和p53的表达，并评估二者在OSCC中的关系。
本研究纳入了30例经组织病理学诊断为高分化和中分化的OSCC病例，以研究KAI-1和p53抗体的表达。
对所得结果进行列表，并使用描述性统计分析、单因素方差分析、最小二乘差法和独立样本t检验进行统计分析。
OSCC中KAI-1的阳性率为41.62%，而p53阳性细胞的比例为60.82%。观察到OSCC中KAI-1和p53表达之间存在显著的正相关。
尽管仍需要大量工作来揭示KAI-1和p53表达的作用机制和调控机制，但控制复杂的转移过程对于控制OSCC以及其他类型恶性肿瘤的肿瘤生物学、改善受影响患者的预后以及帮助预防即将接受治疗和正在接受治疗的患者未来发生转移具有重要意义。
