Katsanevaki Vikentia J, Kalyvianaki Maria I, Kavroulaki Dimitra S, Pallikaris Ioannis G
Institute of Vision & Optics, Heraklion, Greece.
Ophthalmology. 2007 Jun;114(6):1111-7. doi: 10.1016/j.ophtha.2006.08.052. Epub 2007 Feb 23.
To evaluate the clinical results of epi-LASIK for the treatment of low to moderate myopia and myopic astigmatism.
Retrospective, noncomparative, interventional case series.
Two hundred thirty-four eyes of 138 patients underwent epi-LASIK for the correction of low to moderate myopia. Mean preoperative spherical equivalent ranged from -1.0 to -7.25 diopters (D) (-3.74+/-1.46, mean+/-standard deviation [SD]) and baseline logarithm of the minimum angle of resolution (logMAR) best spectacle-corrected visual acuity (BSCVA) from 0.10 to -0.18 (mean+/-SD, 0.00+/-0.06).
All enrolled eyes underwent epi-LASIK using the Centurion SES epikeratome (Norwood Abbey EyeCare, Victoria, Australia) and the Allegretto (Wavelight Laser Technologie AG, Erlangen, Germany) laser platform. The enrolled patients were followed up daily until the epithelial healing was complete as well as at the 1-, 3-, 6-, and 12-month postoperative intervals.
The main parameters assessed were subjective evaluation of postoperative pain, uncorrected visual acuity (UCVA) and BSCVA, manifest refraction, haze grade, and contrast sensitivity of the operated eyes.
The mean epithelial healing time was 4.70+/-0.87 days (range, 3-7 days), with mean logMAR UCVA on the day of reepithelization of 0.26+/-0.14 (range, 0.7-0.0). One year after the treatment, the spherical equivalent of the treated eyes (n = 222) ranged from -1.25 to +0.625 D (mean+/-SD, -0.18+/-0.6 D), with 80.33% of the eyes within 0.5 D (96.72% within 1 D) of the attempted correction. At the same interval, 86% of the eyes had clear corneas and 14% clinically insignificant (trace) haze, whereas 60% of the eyes had a line gain of 1 or more lines of BSCVA. Mean logMAR contrast sensitivity of the treated eyes at 4 different spatial frequencies was improved or remained unchanged throughout the follow-up period.
One-year visual and refractive results after epi-LASIK suggest that it is a safe and efficient method for the correction of low to moderate myopia and myopic astigmatism.
评估准分子上皮下角膜磨镶术（epi-LASIK）治疗低度至中度近视及近视散光的临床效果。
回顾性、非对照、干预性病例系列研究。
138例患者的234只眼接受了epi-LASIK治疗低度至中度近视。术前平均等效球镜度范围为-1.0至-7.25屈光度（D）（-3.74±1.46，平均值±标准差[SD]），最佳矫正视力（BSCVA）的最小分辨角对数（logMAR）基线值为0.10至-0.18（平均值±标准差，0.00±0.06）。
所有纳入的眼睛均使用Centurion SES角膜上皮刀（澳大利亚维多利亚州诺伍德阿比眼科护理公司）和Allegretto（德国埃尔兰根威视光激光技术公司）激光平台进行epi-LASIK手术。对纳入的患者进行每日随访，直至上皮愈合完成，以及术后1、3、6和12个月进行随访。
评估的主要参数包括对手术眼术后疼痛的主观评价、裸眼视力（UCVA）和BSCVA、显验光、 haze分级以及对比敏感度。
平均上皮愈合时间为4.70±0.87天（范围3 - 7天），上皮重新形成当天的平均logMAR UCVA为0.26±0.14（范围0.7 - 0.0）。治疗后一年，治疗眼（n = 222）的等效球镜度范围为-1.25至+0.625 D（平均值±标准差，-0.18±0.6 D），80.33%的眼睛屈光度在预期矫正值的0.5 D范围内（96.72%在1 D范围内）。在同一时间间隔，86%的眼睛角膜清晰，14%有临床意义不显著（微量）的haze，而60%的眼睛BSCVA提高了1行或更多行。在整个随访期间，治疗眼在4种不同空间频率下的平均logMAR对比敏感度有所提高或保持不变。
epi-LASIK术后一年的视力和屈光结果表明，它是一种治疗低度至中度近视及近视散光的安全有效的方法。
