Ott Claudia, Heinmöller Ernst, Gaumann Andreas, Schölmerich Jürgen, Klebl Frank
Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, Regensburg, Germany.
Med Klin (Munich). 2007 Feb 15;102(2):127-35. doi: 10.1007/s00063-007-1013-8.
Due to the fatal prognosis of pancreatic carcinoma, great efforts have been made to investigate precursor lesions of invasive neoplasia during the last few years. Pancreatic intraepithelial neoplasias (PanIN) have been recognized as precursor lesions of ductal adenocarcinoma, and are classified into different grades from PanIN-1A, -1B, -2, to -3. Molecular analyses have helped to define a progression model for pancreatic neoplasia. The most important step seems to be the occurrence of a PanIN-3 lesion defining a high risk of malignant transformation. As in PanINs, different types of intraductal papillary-mucinous neoplasms (IPMN) can be discriminated ranging from benign to invasive lesions. Becoming invasive, some of these tumors appear as ductal adenocarcinoma, others as colloid carcinoma with a much better prognosis. In this review, the characteristics of these two precursor lesions and their genetic alterations are summarized.
由于胰腺癌的预后不佳，在过去几年中人们付出了巨大努力来研究浸润性肿瘤的前驱病变。胰腺上皮内瘤变（PanIN）已被确认为导管腺癌的前驱病变，并分为从PanIN-1A、-1B、-2到-3的不同等级。分子分析有助于确定胰腺肿瘤的进展模型。最重要的步骤似乎是出现PanIN-3病变，这表明恶性转化的风险很高。与PanINs一样，不同类型的导管内乳头状黏液性肿瘤（IPMN）可以从良性到浸润性病变进行区分。其中一些肿瘤发生浸润时，表现为导管腺癌，另一些则表现为预后较好的黏液腺癌。在这篇综述中，总结了这两种前驱病变的特征及其基因改变。
