两种人类补体C4同种型之间的结构差异会影响体液免疫反应。
Structural differences between the two human complement C4 isotypes affect the humoral immune response.
作者信息
Finco O, Li S, Cuccia M, Rosen F S, Carroll M C
机构信息
Department of Pathology Harvard Medical School, Boston, Massachusetts 02115.
出版信息
J Exp Med. 1992 Feb 1;175(2):537-43. doi: 10.1084/jem.175.2.537.
Abstract
An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not.
摘要
一种动物模型已被用于解决人类C4的两种同种型，即C4A和C4B之间已知结构差异的生物学重要性问题。缺乏C4的豚鼠用人类C4A或C4B蛋白进行短暂重建，并用噬菌体φX174免疫。这项研究的结果表明，用C4A重建的动物产生了二次反应，即从IgM转换为IgG；而用C4B重建的动物则没有。
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