Lateef Tarannum Musvee, Nelson Karin B
Department of Neurology, Children's National Medical Center, Washington, DC 20010, USA.
Curr Neurol Neurosci Rep. 2007 Mar;7(2):133-8. doi: 10.1007/s11910-007-0008-4.
Clinical studies have extensively documented the various risks posed by in utero exposure to antiepileptic drugs (AEDs). However, it is difficult to sort out the extent to which any given AED is responsible for a particular outcome, given the disparities in patients taking the drugs, their type and severity of epilepsy, and the various possible AEDs, as well as the vast number of outcomes that could be assessed. This review focuses on AED exposure during pregnancy and how it affects the risks of neonatal morbidity and major congenital malformations.
临床研究已广泛记录了子宫内接触抗癫痫药物（AEDs）所带来的各种风险。然而，鉴于服用这些药物的患者存在差异、癫痫的类型和严重程度不同、可用的AED种类繁多，以及可评估的结果数量众多，很难确定任何一种特定的AED对特定结果的影响程度。本综述重点关注孕期接触AEDs的情况及其对新生儿发病风险和主要先天性畸形的影响。
