Campanati Anna, Bernardini Maria Luisa, Gesuita Rosaria, Offidani Annamaria
Dermatological Clinic, Clinica Dermatologica, Ospedale Torrette, Via Conca 71, Ancona 60020, Italy.
Eur J Dermatol. 2007 Jan-Feb;17(1):52-4. doi: 10.1684/ejd.2007.0094. Epub 2007 Feb 27.
Botulinum toxin is a safe and effective treatment for idiopatic focal axillary and palmar hyperhidrosis, but very few data are reported in the literature on its effect on plantar idiopatic hyperhidrosis. The current study was undertaken to investigate the impact of BTX-A administration on sweat production and quality of life in patients suffering from plantar hyperhidrosis. Ten patients with idiopathic, recalcitrant plantar hyperhidrosis were included in a pilot study and underwent intradermal injections with 100 MU of BTX-A in the plantar skin, bilaterally. All the patients were followed for 16 weeks after treatment with objective (Minor's test) and subjective (DLQI test) evaluation. Patients experienced an improvement of symptoms with a significant decrease of Minor's test and DLQI levels for 12 weeks. No significant side effects occurred in any treated patient. BTX-A seems to be a promising treatment for plantar hyperhidrosis. However, clinical trials on larger patient series are needed in order to evaluate its safety and effectiveness for this application.
肉毒杆菌毒素是治疗特发性局灶性腋窝和手掌多汗症的一种安全有效的方法，但关于其对足底特发性多汗症影响的文献报道极少。本研究旨在探讨A型肉毒毒素（BTX-A）给药对足底多汗症患者汗液分泌及生活质量的影响。10例患有特发性、顽固性足底多汗症的患者纳入一项初步研究，并在双侧足底皮肤进行皮内注射100 MU的BTX-A。治疗后对所有患者进行了16周的随访，采用客观（米诺氏试验）和主观（皮肤病生活质量指数DLQI试验）评估。患者症状有所改善，米诺氏试验和DLQI水平在12周内显著下降。所有接受治疗的患者均未出现明显副作用。BTX-A似乎是治疗足底多汗症的一种有前景的方法。然而，需要对更多患者进行临床试验，以评估其在该应用中的安全性和有效性。
