Truupyl'd T N
Arkh Anat Gistol Embriol. 1975 May;68(5):31-7.
The functional activity of the regenerating cortex was studied in 90 female albino rats (150-200 g) after ablation of the right adrenal and enucleation of the left one. In the period of active growth of the regenerating tissue (10 days after operation) the functional activity of parenchymatous cells was low which is evidenced by poor content of both lipids and "ketosteroids". In parallel with reparation of the adrenal adrenocortical tissue mass the content of physiologically active substances was also restored (20 days after operation). After injection of hydrocortizone (daily dosage 2,5 mg) the growth and differentiation of the bundle-reticular zone in the regenerating area was inhibited. In the glomerular zone the reactions to lipids and "ketosteroids" were mainly similar to those in the glomerular zone of intact adrenal. After injection of ACTH (daily dosage 5 or 10 mg) during 10 days the regenerating area was functionally better developed than in the control since moderately pronounced reactions to "ketosteroids" and lipids appeared in it. Fairly high content of these substances in the regenerated cortex after 20 days of injections of ACTH (10 units) as well as presence of secondary necrobiotic changes pointed to functional overstrain of the newly formed organ.
在90只雌性白化大鼠（体重150 - 200克）身上研究了右侧肾上腺切除并摘除左侧肾上腺后再生皮质的功能活动。在再生组织活跃生长阶段（术后10天），实质细胞的功能活动较低，这可由脂质和“酮类固醇”含量较低得以证明。随着肾上腺皮质组织量的修复，生理活性物质的含量也得以恢复（术后20天）。注射氢化可的松（每日剂量2.5毫克）后，再生区域束状 - 网状带的生长和分化受到抑制。在球状带，对脂质和“酮类固醇”的反应主要与完整肾上腺球状带的反应相似。在连续10天注射促肾上腺皮质激素（每日剂量5或10毫克）后，再生区域在功能上比对照组发育得更好，因为其中出现了对“酮类固醇”和脂质的中度明显反应。在注射促肾上腺皮质激素（10单位）20天后，再生皮质中这些物质的含量相当高，以及出现继发性坏死变化，表明新形成器官的功能过度紧张。
