Nifedipine decreases the mitotic activity of adrenocortical cells in early stage of adrenal regeneration.

The influence of nifedipine, a calcium channel antagonist, on adrenal regeneration was investigated by evaluation of mitotic activity of adrenocortical cells. It was found, that nifedipine given at a daily dose of 10 mg/kg, reduced the proliferation of regenerating adrenal cortex on the fourth day after adrenal enucleation, but the inhibitory effect of nifedipine became insignificant on the eighth day after the operation.