使用DNA微阵列对持续暴露于镉的大鼠肾细胞进行转录组分析。

Transcriptome analysis of rat kidney cells continuously exposed to cadmium using DNA microarray.

作者信息

Ohba Ken-ichi, Okawa Youhei, Matsumoto Yuki, Nakamura Yasuhiro, Ohta Hisayoshi

机构信息

Department of Health Administration, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

出版信息

J Toxicol Sci. 2007 Feb;32(1):103-5. doi: 10.2131/jts.32.103.

DOI:10.2131/jts.32.103

PMID:17327699

Abstract

To examine the transcriptional responses of rat kidney cells continuously exposed to cadmium, we performed DNA microarray analysis. Cadmium increased levels of expression of 27 genes, including genes for Mt1, Mt2, GSTa3 and B2m and reduced those of 4 genes.

摘要

为了研究持续暴露于镉的大鼠肾细胞的转录反应，我们进行了DNA微阵列分析。镉增加了27个基因的表达水平，包括金属硫蛋白1（Mt1）、金属硫蛋白2（Mt2）、谷胱甘肽S-转移酶a3（GSTa3）和β2微球蛋白（B2m）的基因，并降低了4个基因的表达水平。