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黑腹果蝇乙醇脱氢酶基因座上电泳相同的等位基因之间的变异。

Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster.

作者信息

Thörig E W, Schoone A A, Scharloo W

出版信息

Biochem Genet. 1975 Oct;13(9-10):721-31. doi: 10.1007/BF00484929.

DOI:10.1007/BF00484929
PMID:173280
Abstract

A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F enzyme is inactivated rapidly at 40 C, ADH 7lk is still active. Also, ADH S is not inactivated at this temperature, but has a far lower activity per fly than ADH 7lk. Genetic analysis showed that the new variant is an allele of the Adh locus.

摘要

在黑腹果蝇的一个实验室种群中发现了一种新的乙醇脱氢酶变体（ADH 7lk）。该种群中的ADH在丙烯酰胺和琼脂上的电泳迁移率与F变体相同。在15至25摄氏度之间的温度下，其活性水平与F型果蝇中的水平相似。但是，虽然ADH F酶在40摄氏度时会迅速失活，但ADH 7lk仍然具有活性。此外，ADH S在这个温度下不会失活，但每只果蝇的活性远低于ADH 7lk。遗传分析表明，这种新变体是Adh基因座的一个等位基因。

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Alcohol Dehydrogenase in Drosophila melanogaster: Isozymes and Genetic Variants.果蝇中的醇脱氢酶：同工酶和遗传变异。
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Graphical determination of the dissociation constants for two-substrate enzyme systems.双底物酶系统解离常数的图形测定法。
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6-Phosphogluconate dehydrogenase activity variants in Musca domestica L.: A further allele at the Pgd locus as proved by densitometric assay.家蝇6-磷酸葡萄糖酸脱氢酶活性变体：通过光密度测定法证实Pgd位点存在另一个等位基因。
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Assessment of variability within electromorphs of alcohol dehydrogenase in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶电形态内变异性的评估。
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The purification and biochemical properties of alcohol dehydrogenase--"fast (Chateau Douglas)" from Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶——“快速型（道格拉斯城堡）”的纯化及生化特性
Biochem Genet. 1984 Jun;22(5-6):529-49. doi: 10.1007/BF00484521.
10
Alcohol dehydrogenase thermostability variants in Drosophila melanogaster: comparison of activity ratios and enzyme levels.黑腹果蝇中乙醇脱氢酶的热稳定性变体：活性比率与酶水平的比较
Biochem Genet. 1983 Dec;21(11-12):1071-88. doi: 10.1007/BF00488460.
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Experientia. 1972 Aug 15;28(8):975-6. doi: 10.1007/BF01924982.
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Molecular heterosis for heat-sensitive enzyme alleles.热敏感酶等位基因的分子杂种优势。
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Still more genetic variability in natural populations.自然种群中仍存在更多的遗传变异性。
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Biochem Genet. 1974 Feb;11(2):155-65. doi: 10.1007/BF00485771.