果蝇中Notch基因座的作用。I. Notch8缺陷对线粒体酶的影响。

The action of the notch locus in Drosophila melanogaster. I. Effects of the notch8 deficiency on mitochondrial enzymes.

作者信息

Thörig G E, Heinstra P W, Scharloo W

出版信息

Mol Gen Genet. 1981;182(1):31-8. doi: 10.1007/BF00422763.

Abstract

It is shown that the Notch8 deficiency in Drosophila melanogaster affects a number of enzyme activities localized in the mitochondria, such as NADH oxidase (activity of the complete respiratory chain), NADH dehydrogenase (the first step in the respiratory chain before transfer to ubiquinone), Succinate dehydrogenase and alpha-glycerophosphate dehydrogenase. The experiments reported here do not exclude the possibility of involvement of other genes in the deficiency. The effect of duplications of the Notch locus on NADH oxidase and NADH dehydrogenase suggest that the locus determines the enzyme activities. The dosage effects of the Notch locus on activity suggest that this locus contains the structural genes for these enzymes.

摘要

研究表明，果蝇中Notch8基因的缺失会影响定位于线粒体中的多种酶的活性，如NADH氧化酶（完整呼吸链的活性）、NADH脱氢酶（呼吸链中在传递给泛醌之前的第一步）、琥珀酸脱氢酶和α-甘油磷酸脱氢酶。此处报道的实验并未排除其他基因参与该缺失过程的可能性。Notch基因座重复对NADH氧化酶和NADH脱氢酶的影响表明该基因座决定了酶的活性。Notch基因座对活性的剂量效应表明该基因座包含这些酶的结构基因。