Gohle Doris, Juckel Georg, Mavrogiorgou Paraskevi, Pogarell Oliver, Mulert Christoph, Rujescu Dan, Giegling Ina, Zaudig Michael, Hegerl Ulrich
Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
J Psychiatr Res. 2008 Mar;42(4):297-303. doi: 10.1016/j.jpsychires.2007.01.003. Epub 2007 Feb 27.
Neuroimaging studies in recent years suggest that cortical hyperactivity associated with more aroused cognitive processes and overfocussed attention is involved in the pathogenesis of obsessive-compulsive disorder (OCD), which was electrophysiologically supported by an own pilot-study in a small sample of stabilized OCD patients. To replicate this first finding, the hypothesis of cortical hyperactivity was studied by measuring auditory event-related P300 subcomponents, especially the amplitude of the P3a and P3b subcomponent, in a large sample of acutely ill and unmedicated patients with OCD. The P300 of 63 patients with OCD (30 males, 33 females, 33.7+/-10.2 years old; 25.4+/-5.4 points at Yale-Brown-Obsessive-Compulsive-Scale (Y-BOCS)) was separated with dipole source analysis (BESA) into their subcomponents P3a and P3b, and compared to the P300 subcomponents of 63 gender and age matched healthy controls. No difference in the amplitude of P3a was found, but OCD patients had significantly larger amplitudes of P3b than the healthy controls, which replicates the results of the pilot study. Once again, our findings point to a hyperactivated cortical state also of temporo-parietal and hippocampal regions in OCD.
近年来的神经影像学研究表明，与认知过程更加活跃和注意力过度集中相关的皮质功能亢进参与了强迫症（OCD）的发病机制，这在一项针对一小部分病情稳定的强迫症患者的初步研究中得到了电生理学支持。为了重复这一初步发现，通过测量大量急性发病且未接受药物治疗的强迫症患者的听觉事件相关P300子成分，特别是P3a和P3b子成分的幅度，对皮质功能亢进的假设进行了研究。对63名强迫症患者（30名男性，33名女性，年龄33.7±10.2岁；耶鲁-布朗强迫症量表（Y-BOCS）评分为25.4±5.4分）的P300进行偶极子源分析（BESA），将其分离为P3a和P3b子成分，并与63名性别和年龄匹配的健康对照者的P300子成分进行比较。结果发现，P3a的幅度没有差异，但强迫症患者的P3b幅度显著大于健康对照者，这重复了初步研究的结果。我们的研究结果再次表明，强迫症患者的颞顶叶和海马区皮质状态也处于功能亢进状态。
