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开放性根治性前列腺切除术后横纹括约肌后部修复后早期控尿功能恢复

Early continence recovery after open radical prostatectomy with restoration of the posterior aspect of the rhabdosphincter.

作者信息

Rocco Francesco, Carmignani Luca, Acquati Pietro, Gadda Franco, Dell'Orto Paolo, Rocco Bernardo, Casellato Stefano, Gazzano Giacomo, Consonni Dario

机构信息

Clinica Urologica I, Università degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy.

出版信息

Eur Urol. 2007 Aug;52(2):376-83. doi: 10.1016/j.eururo.2007.01.109. Epub 2007 Feb 12.

Abstract

OBJECTIVES

We believe early incontinence after radical retropubic prostatectomy (RRP) is mainly due to the shortening of the sphincter's anatomic and functional length as a result of caudal retraction of the urethral sphincteric complex and disruption of the posterior median fibrous raphe. We illustrate a technique of anatomic and functional reconstruction of the rhabdosphincter (RS) aimed at achieving early continence recovery after RRP. Our modification to the Walsh RRP avoids caudal retraction of the urethrosphincteric complex and reconstructs the posterior fibrous raphe.

METHODS

Prior to completion of the vesicourethral anastomosis, the posterior fibrous tissues of the sphincter are joined to the residual Denonvilliers fascia on the posterior bladder wall 1-2 cm cephalad and dorsally to the new bladder neck. The study end point was assessment of early and long-term continence rate. Modified RRP (group 1: 250 patients) was compared with unmodified RRP (historical group 2: 50 patients). A crude comparison of treatment effect was assessed by using Pearson chi-square. Multiple logistic regression was used to assess treatment efficacy at discharge, 1, 3, and 12 mo, while taking into account age, pathologic stage, and Gleason score. Continence was defined as 0-1 pad per day.

RESULTS

Patients in group 1 achieved significantly better continence at discharge (62.4% vs. 14.0%), 1 mo (74.0% vs. 30%), and 3 mo of follow-up (85.2% vs. 46%); long-term recovery was similar in the two treatment groups (94% vs. 90%).

CONCLUSIONS

The technical modification that we proposed achieved a substantial and significant reduction in time to continence with no adverse effects.

摘要

目的

我们认为耻骨后根治性前列腺切除术(RRP)后早期尿失禁主要是由于尿道括约肌复合体向尾侧回缩以及后正中纤维缝襞中断,导致括约肌解剖和功能长度缩短。我们阐述一种横纹括约肌(RS)解剖和功能重建技术,旨在RRP后实现早期控尿恢复。我们对Walsh RRP术式的改良避免了尿道括约肌复合体向尾侧回缩,并重建了后纤维缝襞。

方法

在完成膀胱尿道吻合之前,将括约肌的后纤维组织与膀胱后壁残留的Denonvilliers筋膜在头侧1-2 cm处相连,并在背侧与新的膀胱颈相连。研究终点是评估早期和长期控尿率。将改良RRP(第1组:250例患者)与未改良RRP(历史第2组:50例患者)进行比较。采用Pearson卡方检验对治疗效果进行粗略比较。采用多元逻辑回归评估出院时、1个月、3个月和12个月时的治疗效果,同时考虑年龄、病理分期和Gleason评分。控尿定义为每天使用0-1片尿垫。

结果

第1组患者在出院时(62.4%对14.0%)、1个月时(74.0%对30%)和3个月随访时(85.2%对46%)的控尿情况明显更好;两个治疗组的长期恢复情况相似(94%对90%)。

结论

我们提出的技术改良显著缩短了控尿时间,且无不良影响。

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