Bihl Florian, Narayan Murli, Chisholm John V, Henry Leah M, Suscovich Todd J, Brown Elizabeth E, Welzel Tania M, Kaufmann Daniel E, Zaman Tauheed M, Dollard Sheila, Martin Jeff N, Wang Fred, Scadden David T, Kaye Kenneth M, Brander Christian
Partners AIDS Research Center, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129-2000, USA.
J Virol. 2007 May;81(9):4904-8. doi: 10.1128/JVI.02509-06. Epub 2007 Feb 28.
The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
针对卡波西肉瘤相关疱疹病毒（KSHV）的细胞免疫特征尚不明确，也未与针对其他人类疱疹病毒的T细胞反应进行比较。在此，我们鉴定了KSHV特异性细胞免疫的新的主要靶点，并将其与另一种人类γ疱疹病毒——爱泼斯坦-巴尔病毒中针对裂解性和潜伏性抗原的T细胞进行比较。数据鉴定出了Orf57蛋白中一个新的HLA - B57和HLA - B58限制性表位，并显示靶向裂解性或潜伏性KSHV和EBV编码抗原的细胞在免疫表型和功能反应模式上始终存在密切相似性，这表明在诱导这些反应过程中存在共同机制。
