Seeley William W, Menon Vinod, Schatzberg Alan F, Keller Jennifer, Glover Gary H, Kenna Heather, Reiss Allan L, Greicius Michael D
Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USa.
J Neurosci. 2007 Feb 28;27(9):2349-56. doi: 10.1523/JNEUROSCI.5587-06.2007.
Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.
神经回路的变化，无论是遗传的还是后天获得的，都可能是思想、情感和行为模式中重要个体差异的基础。在这里，我们使用无任务连接性分析来分离和表征在功能磁共振成像任务中通常共同激活的两个不同网络。我们识别出一个“突显网络”，以背侧前扣带回（dACC）和眶额岛叶皮质为锚点，与皮质下和边缘结构有强大的连接，以及一个连接背外侧额叶和顶叶新皮质的“执行控制网络”。这些内在连接网络与扫描仪外测量的功能显示出可分离的相关性。扫描前焦虑评分与突显网络的dACC节点的内在功能连接相关，但与执行控制网络中的任何区域均无关联，而执行任务表现与执行控制网络的外侧顶叶节点相关，但与突显网络中的任何区域均无关联。我们的研究结果表明，对内在连接网络进行无任务分析可能有助于阐明支持人类行为基本方面的神经结构。
