Swensen S J, Morin R L, Schueler B A, Brown L R, Cortese D A, Pairolero P C, Brutinel W M
Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55905.
Radiology. 1992 Feb;182(2):343-7. doi: 10.1148/radiology.182.2.1732947.
The authors hypothesized that the degree of contrast material enhancement of a pulmonary nodule, measured with computed tomography (CT), may indicate the likelihood of malignancy. Fifty-two patients with uncalcified solitary pulmonary nodules (diameter, 6-30 mm) were studied. Five single serial thin-section CT scans were obtained at 1-minute intervals after injection of 100 mL of nonionic contrast material. Twenty-two patients were excluded because the diagnosis was not clearly established: The observation period was less than 2 years, or the examination was technically inadequate. Malignant nodules were identified in 23 of the 30 remaining patients, and benign nodules were identified in seven. Within the first 2 minutes after the injection, all the malignant nodules had enhanced by 20 HU or greater (only one benign nodule had that degree of enhancement). The authors conclude that the degree of contrast material enhancement of pulmonary nodules as measured with CT may indicate the likelihood of malignancy.
作者们推测，通过计算机断层扫描（CT）测量的肺结节对比剂增强程度可能表明恶性的可能性。对52例患有未钙化孤立性肺结节（直径6 - 30毫米）的患者进行了研究。在注射100毫升非离子型对比剂后，每隔1分钟进行5次单层连续薄层CT扫描。22例患者被排除，因为诊断不明确：观察期少于2年，或检查技术上不充分。在其余30例患者中，23例发现为恶性结节，7例为良性结节。在注射后的前2分钟内，所有恶性结节增强20 HU或更多（只有1个良性结节有那样的增强程度）。作者得出结论，CT测量的肺结节对比剂增强程度可能表明恶性的可能性。
