Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.
Psychiatr Clin North Am. 2023 Mar;46(1):39-51. doi: 10.1016/j.psc.2022.11.003. Epub 2022 Dec 13.
A wealth of evidence has shown that genetics plays a major role in susceptibility to obsessive-compulsive disorder (OCD) and all of its related disorders. Several large-scale, collaborative efforts using modern genomic methods are beginning to reveal the genetic architecture of these traits and identify long-sought risk genes. In this article, we summarize current OCD and related disorder genomic knowledge and explain how to communicate this information to patients and their families. The article concludes with a discussion of how genomic discovery in OCD and related disorders can inform our understanding of disease etiology and provide novel targets for therapeutic development.
大量证据表明，遗传学在强迫症（OCD）及其所有相关障碍的易感性中起着重要作用。一些使用现代基因组方法的大规模合作研究开始揭示这些特征的遗传结构，并确定长期以来寻求的风险基因。本文总结了目前 OCD 和相关障碍的基因组知识，并解释了如何将这些信息传达给患者及其家属。本文最后讨论了 OCD 和相关障碍中的基因组发现如何帮助我们理解疾病病因，并为治疗开发提供新的靶点。
