Deshpande Aniruddha J, Buske Christian
Department of Medicine III, Klinikum Grosshadern, Munich, Germany.
Cell Cycle. 2007 Mar 1;6(5):543-5. doi: 10.4161/cc.6.5.3968. Epub 2007 Mar 26.
Mouse models have demonstrated that both hematopoietic stem cells (HSCs) as well as downstream myeloid progenitors can be targets of transformation in AML. We recently showed in a murine model of the CALM/AF10 fusion gene positive leukemia, that progenitors with lymphoid characteristics can be leukemic stem cell (LSC) candidates in AML. We could demonstrate that the LSC candidate in the CALM/AF10 murine model was positive for the lymphoid associated surface antigen B220, which was not expressed by the leukemic bulk or the normal HSC pool. This offers the intriguing possibility to target the LSCs with antibodies that spare the normal stem cell.
小鼠模型已证明，造血干细胞（HSCs）以及下游髓系祖细胞都可能是急性髓系白血病（AML）转化的靶点。我们最近在CALM/AF10融合基因阳性白血病的小鼠模型中发现，具有淋巴样特征的祖细胞可能是AML中的白血病干细胞（LSC）候选细胞。我们能够证明，CALM/AF10小鼠模型中的LSC候选细胞对淋巴相关表面抗原B220呈阳性，而白血病细胞群或正常造血干细胞池中均未表达该抗原。这提供了一种有趣的可能性，即可以用抗体靶向LSCs，同时使正常干细胞不受影响。
